Thrombocytopenia is a serious and potentially fatal complication of drug therapy that results either from a decrease in bone marrow platelet production or the excessive destruction of circulating platelets. Although multiple mechanisms are responsible for deregulated platelet clearance, the role of programmed platelet death (apoptosis) in drug-induced thrombocytopenia has been relatively under-investigated until recently. Here we review apoptotic signaling pathways in platelets, with a focus on current data that provide mechanistic insights into drug-induced apoptosis and thrombocytopenia.

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药物性血小板减少症：关注血小板凋亡

血小板减少症是药物治疗的一种严重且可能致命的并发症，其原因可能是骨髓血小板生成减少或循环血小板过度破坏。尽管多种机制可导致血小板清除失控，但直到最近，程序性血小板死亡（细胞凋亡）在药物诱导的血小板减少症中的作用仍未得到充分研究。在这里，我们回顾了血小板中的凋亡信号通路，重点关注当前数据，这些数据为了解药物诱导的细胞凋亡和血小板减少症提供了机械性见解。