Palladacycle Based Fluorescence Turn-On Probe for Sensitive Detection of Carbon Monoxide,ACS Sensors

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Palladacycle Based Fluorescence Turn-On Probe for Sensitive Detection of Carbon Monoxide
ACS Sensors ( IF 8.2 ) Pub Date : 2018-02-06 00:00:00 , DOI: 10.1021/acssensors.7b00835
Mingtai Sun _{1,

2} , Huan Yu ₂ , Kui Zhang ₂ , Suhua Wang _{1,

2,

3} , Tasawar Hayat _{3,

4} , Ahmed Alsaedi ₃ , Dejian Huang ₅

Affiliation

New selective and sensitive fluorescence probes have always been in great demand for carbon monoxide, an important gasotransmitter molecule, which is involved in critical physiological and pathophysiological processes in the mammalian cardiovascular system. In this work, we synthesized a new palladacycle compound as a fluorescence turn-on probe for selective and quantitative detection of carbon monoxide. The weakly fluorescent probe quickly and selectively reacts with carbon monoxide and releases a highly fluorescent benzimidazole moiety, due to protonolysis of the palladacycle, which greatly enhances the fluorescence intensity. The selective reaction was against interference from other possible coexisting reactive oxygen species, and achieved a detection limit of ∼0.06 μM. Furthermore, the fluorescence turn-on probe was demonstrated with a high cellular uptake rate and was successfully applied for cell imaging of carbon monoxide in living cells.

中文翻译：

基于Palladacycle的荧光开启探针，用于一氧化碳的灵敏检测

一直以来，对新型的选择性和灵敏的荧光探针一直都非常需要一氧化碳，一氧化碳是一种重要的气体传输分子，它参与了哺乳动物心血管系统的关键生理和病理生理过程。在这项工作中，我们合成了一种新的palladacycle化合物作为荧光开启探针，用于选择性和定量检测一氧化碳。弱荧光探针可通过palladacycle的质子分解迅速而选择性地与一氧化碳反应并释放出高度荧光的苯并咪唑部分，从而大大增强了荧光强度。选择性反应不受其他可能共存的活性氧的干扰，检测限达到约0.06μM。此外，

更新日期：2018-02-06

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