7-Nicotinoyl-styrylquinoline (MB96) displays an antiviral activity on HIV-1 infected CEM cell lines and is a promising inhibitor of the serine/threonine-protein Pim-1 kinase. By means of UV-vis spectroscopy supported by theoretical calculations this styrylquinoline is shown to exist in different conformations: the s-trans planar conformation along with other twisted ones with respect to the torsion around the single bond between the quinoline and the phenylethenyl appendage. Hydrogen bonding interactions with the solvent shift the skeleton of the MB96 towards the planar form, enhancing conjugation of π-electrons between the quinoline and the catechol parts, while self-association process seems furthering this planar conformation.

7-烟酰-苯乙烯基喹啉（MB96）对HIV-1感染的CEM细胞系显示抗病毒活性，并且是丝氨酸/苏氨酸蛋白Pim-1激酶的有前途的抑制剂。通过理论计算支持的紫外可见光谱法，该苯乙烯基喹啉以不同的构型存在：就围绕喹啉和苯基乙烯基附属物之间的单键的扭转而言，s-反式平面构型与其他扭曲的构型一起存在。氢键与溶剂的相互作用将MB96的骨架移向平面形式，从而增强了喹啉和邻苯二酚之间的π电子共轭，而自缔合过程似乎进一步促进了该平面构象。