High hydrostatic pressure (HHP) has been known to affect biological systems for >100 years. In this review, we describe the technology of HHP and its effect macromolecules and physiology of eukaryotic cells. We discuss the use of HHP in cancer immunotherapy to kill tumor cells for generation of whole cell and dendritic cell-based vaccines. We further summarize the current use and perspectives of HHP application in biomedicine, specifically in orthopedic surgery and for the viral, microbial and protozoan inactivation to develop vaccines against infectious diseases.

中文翻译：

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癌症免疫疗法和生物医学中的高静水压

高静水压（HHP）会影响生物系统超过100年。在这篇综述中，我们描述了HHP的技术及其对大分子的影响以及真核细胞的生理学。我们讨论了在癌症免疫疗法中使用HHP杀死肿瘤细胞以产生基于全细胞和树突状细胞的疫苗。我们进一步总结了HHP在生物医学中的当前用途和前景，特别是在整形外科中以及用于病毒，微生物和原生动物灭活以开发针对传染病的疫苗方面。