Two recent papers have tackled the fundamental questions of how place fields are formed in a new environment and what plasticity mechanisms contribute to this process. Bittner et al., in their recent publication, discovered a novel plasticity rule that, in contrast to previous rules, spans the behavioral, seconds-long, timescale. Sheffield et al. have monitored, for the first time, dendritic activity during place field formation, and show the emergence of spatially tuned local NMDA spikes in basal dendrites of CA1 neurons. Together, these papers suggest that multiple complementary dendritic plasticity mechanisms may contribute to place field formation in changing environmental contexts.

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可塑性规则的许多世界

最近的两篇论文解决了在新环境中如何形成场所场以及哪些可塑性机制有助于这一过程的基本问题。Bittner 等人在他们最近的出版物中发现了一个新的可塑性规则，与以前的规则相比，它跨越了行为、秒长的时间尺度。谢菲尔德等人。首次监测了位置场形成过程中的树突活动，并显示了 CA1 神经元基底树突中空间调谐局部 NMDA 尖峰的出现。总之，这些论文表明，多种互补的树突可塑性机制可能有助于在不断变化的环境背景下形成场。