Impaired healing of cutaneous wounds and ulcers continues to have a major impact on the quality of life of millions of people. In recent years, the capacity for stem and progenitor cells to promote wound repair has been investigated with evidence that secreted factors are responsible for the observed therapeutic benefits. This review addresses current evidence in support of stem/progenitor cell-derived extracellular vesicles (EVs) as a regenerative therapy for acceleration of wound healing. Encouraging results for local or systemic administration of EVs have been reported in a range of clinically-relevant animal models of cutaneous wounds. Furthermore, a number of plausible mechanisms involving EV-mediated transfer of proteins and RNAs that trigger pro-repair pathways in target cells have been demonstrated experimentally. However, for successful clinical translation in the coming years, further emphasis on standardized experimental protocols, detailed methodological reporting and clear definition of EV-based therapeutic products will be required.

皮肤伤口和溃疡愈合不良继续对数百万人的生活质量产生重大影响。近年来，已经对干细胞和祖细胞促进伤口修复的能力进行了研究，并有证据表明分泌的因子是所观察到的治疗益处的原因。这篇综述提出了支持干/祖细胞源性细胞外囊泡（EVs）作为加速伤口愈合的再生疗法的最新证据。在一系列临床相关的皮肤伤口动物模型中，已经报道了电动汽车局部或全身给药的令人鼓舞的结果。此外，已经通过实验证明了许多可能的机制，这些机制涉及EV介导的蛋白质和RNA的转移，这些蛋白质和RNA在靶细胞中触发促修复途径。然而，