In orthopedic surgery, osteomyelitis (bone infection) is one of the most serious complications in the last few decades and the resident drug delivery is the key strategy to overcome this issue. Combination of bioactive materials with antibiotics is broadly developed for the handling of osteomyelitis which plays a dual role as bone cell growth and as local drug delivery systems for antibiotic delivery. TiO₂-SiO₂ mixtures were fabricated on Ti alloy by anodization method. Chitosan-Lysine (CS-LY) biopolymers were coated on composites by electrodeposition method and followed by gentamicin sulphate (GS) which was loaded as a model drug. The layers were characterized by AT-FTIR, XRD, FE-SEM and EDX methods. The mechanical, anticorrosion, antimicrobial effects and biocompatibility of the glazes were considered. In addition, drug loading, continued and prolonged liberation behaviors of GS from the fabricated coating were studied. The apatite development ability and cell viability are outstanding for CS-LY-3 coated composites. In vitro cell experimentations indicate that osteoblasts show good adhesion and high growth rates for CS-LY-3 coated TiO₂-SiO₂ composite substrate. In conclusion, the surface modification of TiO₂-SiO₂/CS-LY-3 coated Ti alloy could be used as a carrier for GS, not only to eradicate the osteomyelitis caused by Gram-negative and Gram-positive bacteria, but also to repair the bone defect initiated by the infection owing to the tunable nanocomposite degradation.

在整形外科中，骨髓炎（骨感染）是最近几十年来最严重的并发症之一，常驻药物输送是克服这一问题的关键策略。生物活性物质与抗生素的结合已被广泛开发用于骨髓炎的治疗，该骨炎在骨细胞生长和作为抗生素递送的局部药物递送系统中起着双重作用。TiO ₂ -SiO ₂通过阳极氧化法在Ti合金上制备混合物。通过电沉积方法将壳聚糖-赖氨酸（CS-LY）生物聚合物包被在复合材料上，然后加入硫酸庆大霉素（GS）作为模型药物。通过AT-FTIR，XRD，FE-SEM和EDX方法对这些层进行表征。考虑了釉料的机械，防腐，抗菌作用和生物相容性。此外，还研究了载药量，GS从制成的涂层中持续和长时间的释放行为。磷灰石的开发能力和细胞活力对于CS-LY-3涂层复合材料而言非常出色。体外细胞实验表明，对于CS-LY-3涂层的TiO ₂ -SiO ₂，成骨细胞表现出良好的粘附性和高生长速率复合基材。总之，TiO ₂ -SiO ₂ / CS-LY-3涂层Ti合金的表面改性可以作为GS的载体，不仅可以根除革兰氏阴性菌和革兰氏阳性菌引起的骨髓炎，而且可以由于可调节的纳米复合材料降解，修复由感染引起的骨缺损。