Memantine is an NMDA receptor antagonist clinically used for the treatment of moderate to severe Alzheimer's disease. Currently, it is the only NMDA receptor antagonist drug marketed against this disease. Despite the large number of publications regarding its clinical and therapeutic use, studies related to its mechanism of action are still inconclusive. Knowledge of drug interactions with cell membranes may lead to the development of novel drugs for neurodegenerative diseases. The present mini-review aims to give an overview of the latest findings regarding the interaction of memantine with cell membranes, specifically with that of the human erythrocyte.

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NMDA受体拮抗剂美金刚与细胞膜相互作用的研究综述

美金刚胺是一种NMDA受体拮抗剂，临床上用于治疗中度至重度阿尔茨海默氏病。当前，它是针对该疾病销售的唯一NMDA受体拮抗剂药物。尽管有关其临床和治疗用途的出版物很多，但有关其作用机理的研究仍无定论。药物与细胞膜相互作用的知识可能导致开发用于神经退行性疾病的新药。本小型综述旨在概述有关美金刚与细胞膜，特别是与人类红细胞相互作用的最新发现。