A new synthesis approach towards biantennary lipids of Guerbet glycoside type was developed based on oleic acid as sustainable resource. Functionalization of the double bond provided access to primary alcohols with α-branched C₁₉-skeleton. Formulation studies with corresponding lactosides indicated formation of vesicles with high assembly stability. A relatively narrow bimodal size distribution of the latter, which turns into a narrow unimodal distribution of small vesicles upon addition of an ionic cosurfactant, suggests potential for a vesicular drug delivery system.

中文翻译：

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基于可再生资源的双天线糖脂方法

基于油酸作为可持续资源，开发了一种新的Guerbet苷型双触角脂质合成方法。双键的官能化提供了接近具有α-支化的C ₁₉骨架的伯醇的途径。用相应的乳糖苷进行制剂研究表明形成具有高组装稳定性的囊泡。后者的相对较窄的双峰尺寸分布，在加入离子型辅助表面活性剂后变成小囊泡的较窄的单峰分布，表明了潜在的囊泡药物递送系统。