The autophagy-lysosome pathway maintains cellular homeostasis and protects against neurodegenerative disorders. Recent findings show that autophagy can be impaired in these diseases, and that the cell activates an alternative Golgi-mediated degradation pathway, leading to expulsion of toxic protein aggregates. Ultimately this process leads to nuclear breakdown and neuronal cell death.

中文翻译：

---

神经退行性变中的自噬：消化不了，吐出来！

自噬-溶酶体途径维持细胞稳态并预防神经退行性疾病。最近的研究结果表明，在这些疾病中，自噬可能会受到损害，并且细胞激活另一种高尔基体介导的降解途径，导致有毒蛋白质聚集体的排出。最终这个过程导致核崩溃和神经元细胞死亡。