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Autophagy in Neurodegeneration: Can’t Digest It, Spit It Out!
Trends in Cell Biology ( IF 13.0 ) Pub Date : 2018-01-31 , DOI: 10.1016/j.tcb.2018.01.001
Valentin J A Barthet 1 , Kevin M Ryan 1
Affiliation  

The autophagy-lysosome pathway maintains cellular homeostasis and protects against neurodegenerative disorders. Recent findings show that autophagy can be impaired in these diseases, and that the cell activates an alternative Golgi-mediated degradation pathway, leading to expulsion of toxic protein aggregates. Ultimately this process leads to nuclear breakdown and neuronal cell death.



中文翻译:


神经退行性变中的自噬:消化不了,吐出来!



自噬-溶酶体途径维持细胞稳态并预防神经退行性疾病。最近的研究结果表明,在这些疾病中,自噬可能会受到损害,并且细胞激活另一种高尔基体介导的降解途径,导致有毒蛋白质聚集体的排出。最终这个过程导致核崩溃和神经元细胞死亡。

更新日期:2018-01-31
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