Biomaterials for Regenerative Medicine Approaches for the Anterior Segment of the Eye,Advanced Healthcare Materials

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Biomaterials for Regenerative Medicine Approaches for the Anterior Segment of the Eye
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-02-01 , DOI: 10.1002/adhm.201701328
Rachel Williams ₁ , Rebecca Lace ₁ , Stephnie Kennedy ₁ , Kyle Doherty ₁ , Hannah Levis ₁

Affiliation

The role of biomaterials in tissue engineering and regenerative medicine strategies to treat vision loss associated with damage to tissues in the anterior segment of the eye has been studied for several years. This has mostly involved replacement and support for the cornea and conjunctiva. These are complex tissues with specific functional requirements for different parts of the tissue. Amniotic membrane (AM) is used in clinical practice to transplant autologous or allogenic cells to the corneal surface. Fibrin gels have also progressed to clinical use under specific conditions. Alternatives to AM such as collagen gels, other natural materials, for example keratin and silks, and synthetic polymers have received considerable attention in laboratory and animal studies. This experience is building a body of evidence to demonstrate the potential of tissue engineering and regenerative medicine in corneal and conjunctival reconstruction and can also lead to other applications in the anterior segment of the eye, for example, the trabecular meshwork. There is a real clinical need for new procedures to overcome vision loss but there are also opportunities for developments in ocular applications to lead to biomaterials innovations for use in other clinical areas.

中文翻译：

眼前节再生医学方法的生物材料

已经研究了生物材料在组织工程和再生医学策略中的作用，该策略用于治疗与眼前段组织损伤相关的视力丧失。这主要涉及角膜和结膜的置换和支持。这些是复杂的组织，对组织的不同部分有特定的功能要求。羊膜（AM）在临床实践中用于将自体或同种异体细胞移植到角膜表面。纤维蛋白凝胶在特定条件下也已经发展到临床应用。AM的替代品，例如胶原蛋白凝胶，其他天然材料（例如角蛋白和丝绸）以及合成聚合物，在实验室和动物研究中受到了相当大的关注。这项经验正在建立证据，以证明组织工程和再生医学在角膜和结膜重建中的潜力，并且还可以导致眼前节的其他应用，例如小梁网。临床上确实需要新的程序来克服视力丧失，但眼科应用的发展也有机会导致生物材料在其他临床领域的创新。

更新日期：2018-02-01

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