Reaction of the Ruppert–Prakash reagent (Me₃SiCF₃) with aromatic aldehydes in the presence of triphenylphosphine, lithium iodide and lithium tetrafluoroborate selectively furnishes gem-difluorinated phosphonium salts. Simple alkaline hydrolysis of these salts results in difluoromethylated products. Thus, one-pot nucleophilic difluoromethylation of aromatic aldehydes using Me₃SiCF₃ has been accomplished. The protocol tolerates electron withdrawing as well as electron donating substituents.

中文翻译：

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使用三甲基（三氟甲基）硅烷（TMSCF ₃）进行芳香族醛的亲核二氟甲基化

在三苯基膦，碘化锂和四氟硼酸锂的存在下，Ruppert-Prakash试剂（Me ₃ SiCF ₃）与芳族醛的反应选择性地提供了宝石二氟化phospho盐。这些盐的简单碱性水解产生二氟甲基化产物。因此，已经实现了使用Me ₃ SiCF ₃一锅法芳香族醛的亲核二氟甲基化。该方案容许吸电子以及给电子取代基。