Nowadays, Green Analytical Chemistry idea is of high importance what impact on the rapid growth in the sample preparation area with special emphasis on sample preparation simplification, miniaturization and automation. Because the derivatization process is often an essential element of the analytical procedure, it should be important to focus on this issue and conduct a series of experiments in order to develop the most favourable conditions. Application of microextraction techniques coupled with the derivatization perfectly meets the specified requirements. Other approaches to perform derivatization process in “green” way include application of eco-friendly solvents/reagents, enhanced parameters such as microwaves or ultrasound and application of in-port, on-column/in-capillary derivatization modes. This review describes factors that allow making derivatization process more green, different modes and ways of derivatization procedures involving less toxic, hazardous reagents/solvents and more efficient forms of energy. Moreover, microextraction techniques that are often coupled to derivatization are described with examples.

如今，绿色分析化学的思想对于影响样品制备领域的快速增长具有重要意义，特别强调样品制备的简化，小型化和自动化。由于衍生化过程通常是分析过程中必不可少的元素，因此应着重研究此问题并进行一系列实验以开发最有利的条件，这一点很重要。微萃取技术与衍生化技术的结合可以完全满足规定的要求。其他以“绿色”方式进行衍生化处理的方法包括应用环保型溶剂/试剂，增强的参数（如微波或超声波）以及端口内，柱上/毛细管内衍生化模式的应用。这篇综述描述了使衍生化过程更加绿色的因素，涉及毒性较小，危险的试剂/溶剂和更有效形式的能源的衍生化过程的不同方式和方式。此外，通过实例描述了经常与衍生化结合的微萃取技术。