The aim of this study was to measure the test–retest reliability of ¹¹C-N,N-dimethyl-2-(2′-amino-4′-hydroxymethylphenylthio)benzylamine (¹¹C-HOMADAM) imaging of serotonin transporter (SERT) density in healthy control subjects. Methods: Two female and 2 male volunteers participated in the study, with each undergoing three 90-min ¹¹C-HOMADAM PET scans. Time–activity curves were derived from SERT-rich structures and fit to 2 models: a simplified reference tissue model and a multilinear graphical model. Binding potential, the ratio of specifically bound uptake to nondisplaceable uptake at equilibrium, was calculated from the model parameter estimates. Ninety-five percent confidence intervals and the intraclass correlation coefficient (ICC) were calculated and adjusted for repeated measures. Results: The ICC values ranged from −0.13 in the dorsal raphe to 0.88 in the caudate nucleus. The highest average ICC values were in the striatum, but other regions were sensitive to measurement outliers. Conclusion: Good-to-excellent test–retest reliability was observed for SERT binding in the striatum. The dorsal raphe ICC value was sensitive to a measurement outlier. ¹¹C-HOMADAM binding potential calculated from the simplified reference tissue model and the multilinear graphical model were robust and in good agreement.

本研究的目的是测量的重测信度¹¹ C- N，N-二甲基-2-（2'-氨基-4'- hydroxymethylphenylthio）苄胺（¹¹ C-HOMADAM）血清素转运蛋白（SERT）的成像健康对照对象中的密度。方法： 2名女性志愿者和2名男性志愿者参加了这项研究，每名志愿者进行了3次90分钟的¹¹C-HOMADAM PET扫描。时间-活动曲线来自富含SERT的结构，并适合2种模型：简化的参考组织模型和多线性图形模型。从模型参数估计值计算结合电位，即平衡状态下特异性结合的摄取量与不可替代的摄取量之比。百分之九十五的置信区间和类内相关系数（ICC）被计算和调整以用于重复测量。结果： ICC值的范围从背缝的-0.13到尾状核的0.88。平均最高ICC值位于纹状体中，但其他区域对测量异常值敏感。结论：对于纹状体中的SERT结合，观察到了很好的再测信度。背缝ICC值对测量值异常敏感。从简化的参考组织模型和多线性图形模型计算得出的¹¹ C-HOMADAM结合力很强并且吻合良好。