Vinca alkaloids, the well-known tubulin-binding agents, are widely used for the clinical treatment of malignant tumors. However, little attention has been paid to their vascular disrupting effects, and the underlying mechanisms remain largely unknown. This study aims to investigate the vascular disrupting effect and the underlying mechanisms of vinca alkaloids.

中文翻译：

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去乙酰长春碱一酰肼通过促进VE-钙黏着蛋白内在化破坏肿瘤血管

长春花生物碱，众所周知的微管蛋白结合剂，被广泛用于恶性肿瘤的临床治疗。但是，对其血管破坏作用的关注很少，其潜在机制在很大程度上仍然未知。这项研究旨在调查长春花生物碱的血管破坏作用及其潜在机制。