Thoracic aortic dissection (TAD) is an aggressive and life-threatening vascular disease and there is no effective means of early diagnosis of dissection. Type IV collagen (Col-IV) is a major component of the sub-endothelial basement membrane, which is initially exposed followed by endothelial injury as early-stage event of TAD. So, we want to build a noninvasive diagnostic method to detect early dissection by identifying the exposed Col-IV via MRI.

中文翻译：

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鉴定IV型胶原暴露为早期发现胸主动脉夹层的分子成像靶标

胸主动脉夹层（TAD）是一种侵略性且威胁生命的血管疾病，尚无早期诊断夹层的有效方法。IV型胶原蛋白（Col-IV）是内皮下基底膜的主要成分，该膜最初暴露于TAD的早期阶段，随后受到内皮损伤。因此，我们想建立一种无创诊断方法，以通过MRI识别暴露的Col-IV来检测早期解剖。