Identification of type IV collagen exposure as a molecular imaging target for early detection of thoracic aortic dissection,Theranostics

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Identification of type IV collagen exposure as a molecular imaging target for early detection of thoracic aortic dissection
Theranostics ( IF 12.4 ) Pub Date : 2018-01-01 , DOI: 10.7150/thno.22467
Ke Xu ₁ , Chen Xu ₂ , Yanzhenzi Zhang ₁ , Feiran Qi ₁ , Bingran Yu ₂ , Ping Li ₁ , Lixin Jia ₁ , Yulin Li ₁ , Fu-Jian Xu ₂ , Jie Du ₁

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Thoracic aortic dissection (TAD) is an aggressive and life-threatening vascular disease and there is no effective means of early diagnosis of dissection. Type IV collagen (Col-IV) is a major component of the sub-endothelial basement membrane, which is initially exposed followed by endothelial injury as early-stage event of TAD. So, we want to build a noninvasive diagnostic method to detect early dissection by identifying the exposed Col-IV via MRI.

中文翻译：

鉴定 IV 型胶原蛋白暴露作为早期检测胸主动脉夹层的分子成像目标

胸主动脉夹层（TAD）是一种侵袭性、危及生命的血管疾病，目前尚无有效的早期诊断手段。 IV 型胶原 (Col-IV) 是内皮下基底膜的主要成分，在 TAD 的早期事件中，其最初暴露，随后发生内皮损伤。因此，我们希望建立一种无创诊断方法，通过 MRI 识别暴露的 Col-IV 来检测早期解剖。

更新日期：2018-02-01

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