Topical administration permits targeted, sustained delivery of therapeutics to human skin. Delivery to the skin, however, is typically limited to lipophilic molecules with molecular weight of < 500 Da, capable of crossing the stratum corneum. Nevertheless, there are indications protein delivery may be possible in barrier deficient skin, a condition found in several inflammatory skin diseases such as psoriasis, using novel nanocarrier systems.

中文翻译：

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突破壁垒-使用热敏性纳米凝胶高效局部递送依那西普后有效的抗炎活性

局部给药允许将治疗剂靶向，持续地递送至人皮肤。然而，向皮肤的递送通常限于分子量小于500Da，能够穿过角质层的亲脂性分子。然而，有迹象表明，使用新型纳米载体系统，在屏障障碍型皮肤（一种在多种炎症性皮肤病（如牛皮癣）中发现的疾病）中的蛋白质可能会递送。