During neoplastic development, a multitude of changes in genome-encoded information are progressively selected to confer growth and survival advantages to tumor cells. microRNAs-mRNAs regulatory networks, given their role as a critical layer of robust gene expression control, are frequently altered in neoplasm. However, whether and how these gene perturbations impact metabolic homeostasis remains largely unresolved.

中文翻译：

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MiR-31-5p-ACOX1轴通过前列腺素E2增强口腔鳞状细胞癌的致瘤适应性。

在肿瘤发展过程中，逐步选择基因组编码信息中的许多变化，以赋予肿瘤细胞生长和生存优势。鉴于其作为稳健的基因表达控制的关键层的作用，microRNA-mRNA调控网络在肿瘤中经常发生变化。然而，这些基因扰动是否以及如何影响代谢体内稳态仍很大程度上尚未解决。