Self‐Assembly of Enzyme‐Like Nanofibrous G‐Molecular Hydrogel for Printed Flexible Electrochemical Sensors,Advanced Materials

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Self‐Assembly of Enzyme‐Like Nanofibrous G‐Molecular Hydrogel for Printed Flexible Electrochemical Sensors
Advanced Materials ( IF 27.4 ) Pub Date : 2018-02-01 , DOI: 10.1002/adma.201706887
Ruibo Zhong ₁ , Qian Tang ₁ , Shaopeng Wang ₂ , Hongbo Zhang ₃ , Feng Zhang ₄ , Mingshu Xiao ₁ , Tiantian Man ₁ , Xiangmeng Qu ₁ , Li Li ₁ , Weijia Zhang ₅ , Hao Pei ₁

Affiliation

Conducting hydrogels provide great potential for creating designer shape‐morphing architectures for biomedical applications owing to their unique solid–liquid interface and ease of processability. Here, a novel nanofibrous hydrogel with significant enzyme‐like activity that can be used as “ink” to print flexible electrochemical devices is developed. The nanofibrous hydrogel is self‐assembled from guanosine (G) and KB(OH)₄ with simultaneous incorporation of hemin into the G‐quartet scaffold, giving rise to significant enzyme‐like activity. The rapid switching between the sol and gel states responsive to shear stress enables free‐form fabrication of different patterns. Furthermore, the replication of the G‐quartet wires into a conductive matrix by in situ catalytic deposition of polyaniline on nanofibers is demonstrated, which can be directly printed into a flexible electrochemical electrode. By loading glucose oxidase into this novel hydrogel, a flexible glucose biosensor is developed. This study sheds new light on developing artificial enzymes with new functionalities and on fabrication of flexible bioelectronics.

中文翻译：

类似于酶的纳米纤维G分子水凝胶的自组装，用于印刷柔性电化学传感器

导电水凝胶具有独特的固液界面和易于加工的特性，因此为生物医学应用创建设计师的形状变形体系结构提供了巨大的潜力。在这里，开发了一种具有显着酶样活性的新型纳米纤维水凝胶，可用作“墨水”以印刷柔性电化学装置。纳米纤维水凝胶由鸟苷（G）和KB（OH）₄自组装而成同时将血红素结合到G四重奏支架中，从而产生显着的酶样活性。响应剪切应力，溶胶和凝胶状态之间的快速切换可实现不同图案的自由形式加工。此外，还证明了通过在纳米纤维上原位催化沉积聚苯胺将G四方线复制到导电基质中的方法，可以将其直接印刷到柔性电化学电极中。通过将葡萄糖氧化酶加载到这种新型水凝胶中，开发了一种灵活的葡萄糖生物传感器。这项研究为开发具有新功能的人造酶和制造柔性生物电子学提供了新的思路。

更新日期：2018-02-01

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