Multimodality Imaging of Silica and Silicon Materials In Vivo,Advanced Materials

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Multimodality Imaging of Silica and Silicon Materials In Vivo
Advanced Materials ( IF 27.4 ) Pub Date : 2018-02-01 , DOI: 10.1002/adma.201703651
Didem Şen Karaman ₁ , Mirkka P. Sarparanta ₂ , Jessica M. Rosenholm ₁ , Anu J. Airaksinen ₂

Affiliation

Recent progress in the development of silica‐ and silicon‐based multimodality imaging nanoprobes has advanced their use in image‐guided drug delivery, and the development of novel systems for nanotheranostic and diagnostic applications. As biocompatible and flexibly tunable materials, silica and silicon provide excellent platforms with high clinical potential in nanotheranostic and diagnostic probes with well‐defined morphology and surface chemistry, yielding multifunctional properties. In vivo imaging is of great value in the exploration of methods for improving site‐specific nanotherapeutic delivery by silica‐ and silicon‐based drug‐delivery systems. Multimodality approaches are essential for understanding the biological interactions of nanotherapeutics in the physiological environment in vivo. The aim here is to describe recent advances in the development of in vivo imaging tools based on nanostructured silica and silicon, and their applications in single and multimodality imaging.

中文翻译：

二氧化硅和硅材料的体内多模态成像

基于二氧化硅和硅的多峰成像纳米探针的最新进展已将其用于图像引导药物输送，以及开发了用于纳米热学和诊断应用的新型系统。作为具有生物相容性和灵活可调性的材料，二氧化硅和硅提供了出色的平台，在具有明确形态和表面化学的纳米热学和诊断探针中具有很高的临床潜力，可产生多功能特性。体内成像在探索通过二氧化硅和硅基药物递送系统改善特定部位的纳米治疗药物递送的方法方面具有重要价值。多模式方法对于了解纳米治疗剂在体内生理环境中的生物学相互作用至关重要。

更新日期：2018-02-01

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