Abstract

A regioselective two-step approach to 5-carboxy-1,2,3-triazoles based on palladium-catalyzed carbonylation has been developed. The protocol utilizes readily available 5-iodotriazoles as starting materials. The obtained products were used in the syntheses of fused heterocycles as well as derivatization of the steroidal hormone cortexolone­.

A regioselective two-step approach to 5-carboxy-1,2,3-triazoles based on palladium-catalyzed carbonylation has been developed. The protocol utilizes readily available 5-iodotriazoles as starting materials. The obtained products were used in the syntheses of fused heterocycles as well as derivatization of the steroidal hormone cortexolone­.

中文翻译：

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基于钯催化羰基化的5-羧基1,2,3-三唑区域选择性方法

摘要

已经开发了基于钯催化的羰基化的5-羧基-1,2,3-三唑的区域选择性两步法。该方案利用容易获得的5-碘三唑作为起始原料。所得产物用于稠合杂环的合成以及甾体激素皮质酮的衍生化。

已经开发了基于钯催化的羰基化的5-羧基-1,2,3-三唑的区域选择性两步法。该方案利用容易获得的5-碘三唑作为起始原料。所得产物用于稠合杂环的合成以及甾体激素皮质酮的衍生化。