For decades, RNA has served in a supporting role between the genetic carrier (DNA) and the functional molecules (proteins). It is finally time for RNA to take center stage in all aspects of biology. The retina provides a unique opportunity to dissect the molecular underpinnings of neuronal diversity and disease. Transcriptome profiles of the retina and its resident cell types have unraveled unique features of the RNA landscape. The discovery of distinct RNA molecules and the recognition that RNA processing is a major cause of retinal neurodegeneration have prompted the design of biomarkers and novel therapeutic paradigms. We review here RNA biology as it pertains to the retina, emphasizing new avenues for investigations in development and disease.

中文翻译：

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视网膜发育和疾病中的RNA生物学。

数十年来，RNA一直在遗传载体（DNA）和功能分子（蛋白质）之间起辅助作用。终于到了RNA在生物学各个方面占据中心位置的时候了。视网膜为解剖神经元多样性和疾病的分子基础提供了独特的机会。视网膜的转录组概况及其常驻细胞类型揭示了RNA景观的独特特征。独特的RNA分子的发现以及RNA加工是视网膜神经变性的主要原因的认识促使生物标志物和新型治疗范例的设计。我们在这里回顾与视网膜有关的RNA生物学，着重研究发展和疾病的新途径。