Fabrication of Polymer–Protein Hybrids,Macromolecular Rapid Communications

当前位置： X-MOL 学术 › Macromol. Rapid Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Fabrication of Polymer–Protein Hybrids
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2018-01-31 , DOI: 10.1002/marc.201700737
Yuanyuan Ju ₁ , Yue Zhang ₂ , Hanying Zhao ₁

Affiliation

Rapid developments in organic chemistry and polymer chemistry promote the synthesis of polymer–protein hybrids with different structures and biofunctionalities. In this feature article, recent progress achieved in the synthesis of polymer–protein conjugates, protein–nanoparticle core–shell structures, and polymer–protein nanogels/hydrogels is briefly reviewed. The polymer–protein conjugates can be synthesized by the “grafting‐to” or the “grafting‐from” approach. In this article, different coupling reactions and polymerization methods used in the synthesis of bioconjugates are reviewed. Protein molecules can be immobilized on the surfaces of nanoparticles by covalent or noncovalent linkages. The specific interactions and chemical reactions employed in the synthesis of core–shell structures are discussed. Finally, a general introduction to the synthesis of environmentally responsive polymer–protein nanogels/hydrogels by chemical cross‐linking reactions or molecular recognition is provided.

中文翻译：

聚合物-蛋白质杂化物的制备

有机化学和高分子化学的快速发展促进了具有不同结构和生物功能的高分子-蛋白质杂种的合成。在这篇专题文章中，简要回顾了高分子-蛋白质结合物，蛋白质-纳米颗粒核-壳结构以及高分子-蛋白质纳米凝胶/水凝胶的合成方面的最新进展。可以通过“嫁接”或“嫁接”方法合成高分子-蛋白质共轭物。在本文中，综述了生物共轭物合成中使用的不同偶联反应和聚合方法。可以通过共价或非共价键将蛋白质分子固定在纳米颗粒的表面上。讨论了核-壳结构合成中使用的特定相互作用和化学反应。最后，

更新日期：2018-01-31

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11