Anxiety Cells in a Hippocampal-Hypothalamic Circuit.,Neuron

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Anxiety Cells in a Hippocampal-Hypothalamic Circuit.
Neuron ( IF 14.7 ) Pub Date : 2018-Feb-07 , DOI: 10.1016/j.neuron.2018.01.016
Jessica C Jimenez ₁ , Katy Su ₁ , Alexander R Goldberg ₁ , Victor M Luna ₁ , Jeremy S Biane ₂ , Gokhan Ordek ₁ , Pengcheng Zhou ₃ , Samantha K Ong ₁ , Matthew A Wright ₄ , Larry Zweifel ₅ , Liam Paninski ₆ , René Hen ₁ , Mazen A Kheirbek ₇

Affiliation

Departments of Neuroscience, Psychiatry & Pharmacology, Columbia University, New York, NY, USA; Division of Integrative Neuroscience, Department of Psychiatry, New York State Psychiatric Institute, New York, NY, USA.
Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
Center for the Neural Basis of Cognition and Machine Learning Department, Carnegie Mellon University, Pittsburgh, PA, USA; Departments of Statistics and Neuroscience, Grossman Center for the Statistics of Mind, Center for Theoretical Neuroscience, Kavli Institute for Brain Science, and NeuroTechnology Center, Columbia University, New York, NY, USA.
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Department of Pharmacology, University of Washington, Seattle, WA 98105, USA; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98105, USA.
Departments of Statistics and Neuroscience, Grossman Center for the Statistics of Mind, Center for Theoretical Neuroscience, Kavli Institute for Brain Science, and NeuroTechnology Center, Columbia University, New York, NY, USA.
Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA.

The hippocampus is traditionally thought to transmit contextual information to limbic structures where it acquires valence. Using freely moving calcium imaging and optogenetics, we show that while the dorsal CA1 subregion of the hippocampus is enriched in place cells, ventral CA1 (vCA1) is enriched in anxiety cells that are activated by anxiogenic environments and required for avoidance behavior. Imaging cells defined by their projection target revealed that anxiety cells were enriched in the vCA1 population projecting to the lateral hypothalamic area (LHA) but not to the basal amygdala (BA). Consistent with this selectivity, optogenetic activation of vCA1 terminals in LHA but not BA increased anxiety and avoidance, while activation of terminals in BA but not LHA impaired contextual fear memory. Thus, the hippocampus encodes not only neutral but also valence-related contextual information, and the vCA1-LHA pathway is a direct route by which the hippocampus can rapidly influence innate anxiety behavior.

中文翻译：

海马-下丘脑回路中的焦虑细胞。

传统上认为海马体将上下文信息传递到边缘结构，并在那里获得价。利用自由移动的钙成像和光遗传学，我们发现，虽然海马背侧 CA1 亚区富含定位细胞，但腹侧 CA1 (vCA1) 富含焦虑细胞，这些细胞被焦虑环境激活，是回避行为所必需的。由投射目标定义的成像细胞显示，焦虑细胞在投射到下丘脑外侧区（LHA）但不投射到基底杏仁核（BA）的vCA1群体中富集。与这种选择性一致，LHA（而非 BA）中 vCA1 末端的光遗传学激活会增加焦虑和回避，而 BA（而非 LHA）中末端的激活会损害情境恐惧记忆。因此，海马体不仅编码中性信息，还编码价相关的上下文信息，而vCA1-LHA途径是海马体快速影响先天焦虑行为的直接途径。

更新日期：2018-01-31

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