Abstract

A one-pot synthesis of substituted (dihydro)thieno[2,3-c]chromene derivatives was developed through a Lewis base catalyzed domino Michael addition/intramolecular cyclization reaction between 3-nitro-2H-chromenes and thioamides. The desired (dihydro)thieno[2,3-c]chromene derivatives were prepared with a large substrate scope (22 examples) and excellent diastereoselectivity in moderate to excellent yields.

A one-pot synthesis of substituted (dihydro)thieno[2,3-c]chromene derivatives was developed through a Lewis base catalyzed domino Michael addition/intramolecular cyclization reaction between 3-nitro-2H-chromenes and thioamides. The desired (dihydro)thieno[2,3-c]chromene derivatives were prepared with a large substrate scope (22 examples) and excellent diastereoselectivity in moderate to excellent yields.

中文翻译：

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通过多米诺·迈克尔加成反应/分子内环化反应构建官能化的（二氢）噻吩并[2,3-c]亚甲基衍生物

摘要

通过路易斯碱催化的3-硝基-2 H-色烯与硫代酰胺之间的多米诺骨牌迈克尔加成/分子内环化反应，开发了一锅合成取代的（二氢）噻吩并[2,3- c ]色烯衍生物。制备所需的（二氢）噻吩并[2,3- c ]亚甲基衍生物，具有较大的底物范围（22个实施例），并且以中等至优异的产率具有优异的非对映选择性。

通过路易斯碱催化的3-硝基-2 H-色烯与硫代酰胺之间的多米诺骨牌迈克尔加成/分子内环化反应，开发了一锅合成取代的（二氢）噻吩并[2,3- c ]色烯衍生物。制备所需的（二氢）噻吩并[2,3- c ]亚甲基衍生物，具有较大的底物范围（22个实施例），并且以中等至优异的产率具有优异的非对映选择性。