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Photothermal Effect-Triggered Drug Release from Hydrogen Bonding-Enhanced Polymeric Micelles
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-01-30 00:00:00 , DOI: 10.1021/acs.biomac.7b01702 Yuce Li 1, 2 , Jianxun Ding 2 , Jintao Zhu 1 , Huayu Tian 2 , Xuesi Chen 2
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-01-30 00:00:00 , DOI: 10.1021/acs.biomac.7b01702 Yuce Li 1, 2 , Jianxun Ding 2 , Jintao Zhu 1 , Huayu Tian 2 , Xuesi Chen 2
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Incorporation of noncovalent interactions into hydrophobic cores of polymeric micelles provides the micelles with enhanced physical stability and drug loading efficiency, however, it also creates obstacles for drug release due to the strong interactions between carriers and drugs. Herein, a series of amphiphilic block copolymers based on poly(ethylene glycol)-b-poly(l-lysine) (mPEG-b-PLL) with similar chemical structures, while different hydrogen bonding donors (urethane, urea, and thiourea groups) are synthesized, and their capacities for codelivery of anticancer drug (e.g., doxorubicin) and photothermal agent (e.g., indocyanine green) are investigated. The resulting hybrid micelles display decreased critical micelle concentrations (CMCs) and enhanced micelle stabilities due to the hydrogen bonding between urea groups in the polymers. Moreover, the strong hydrogen bonds between the urea/thiourea groups and drugs provide the carriers with enhanced drug loading efficiencies, decreased micelle sizes, however, slower drug release profiles as well. When exposed to the near-infrared laser irradiation, destabilization of the hydrogen bonding through photothermal effect triggers fast and controlled drug releases from the micelles, which dramatically promotes the aggregation of the drugs in the nuclei, resulting in an enhanced anticancer activity. These results demonstrate that the hydrogen bonding-enhanced micelles are promising carriers for controllable chemo-photothermal synergistic therapy.
中文翻译：
氢键增强型聚合物胶束的光热效应触发药物释放
将非共价相互作用结合到聚合物胶束的疏水核中可为胶束提供增强的物理稳定性和药物装载效率，但是，由于载体与药物之间的强相互作用，它也为药物释放创造了障碍。在本文中，基于聚（乙二醇）的一系列的两亲性嵌段共聚物的- b -聚（升-赖氨酸）（的mPEG- b-PLL）具有相似的化学结构，同时合成了不同的氢键供体（氨基甲酸酯，尿素和硫脲基），并研究了它们的抗癌药（例如阿霉素）和光热剂（例如吲哚菁绿）的代码传递能力。由于聚合物中脲基团之间的氢键作用，所得的杂化胶束显示出降低的临界胶束浓度（CMC）和增强的胶束稳定性。而且，尿素/硫脲基团与药物之间的强氢键为载体提供了更高的载药效率，减小了的胶束尺寸，但是也降低了药物的释放曲线。当暴露于近红外激光辐照下时，通过光热效应引起的氢键的不稳定会触发从胶束中快速且受控地释放药物，大大促进了药物在细胞核中的聚集，从而增强了抗癌活性。这些结果表明，氢键增强的胶束是可控的化学光热协同治疗的有希望的载体。
更新日期：2018-01-30
中文翻译：
氢键增强型聚合物胶束的光热效应触发药物释放
将非共价相互作用结合到聚合物胶束的疏水核中可为胶束提供增强的物理稳定性和药物装载效率，但是，由于载体与药物之间的强相互作用，它也为药物释放创造了障碍。在本文中，基于聚（乙二醇）的一系列的两亲性嵌段共聚物的- b -聚（升-赖氨酸）（的mPEG- b-PLL）具有相似的化学结构，同时合成了不同的氢键供体（氨基甲酸酯，尿素和硫脲基），并研究了它们的抗癌药（例如阿霉素）和光热剂（例如吲哚菁绿）的代码传递能力。由于聚合物中脲基团之间的氢键作用，所得的杂化胶束显示出降低的临界胶束浓度（CMC）和增强的胶束稳定性。而且，尿素/硫脲基团与药物之间的强氢键为载体提供了更高的载药效率，减小了的胶束尺寸，但是也降低了药物的释放曲线。当暴露于近红外激光辐照下时，通过光热效应引起的氢键的不稳定会触发从胶束中快速且受控地释放药物，大大促进了药物在细胞核中的聚集，从而增强了抗癌活性。这些结果表明，氢键增强的胶束是可控的化学光热协同治疗的有希望的载体。
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