Determining the Physical Properties of Molecules with Nanometer-Scale Pores,ACS Sensors

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Determining the Physical Properties of Molecules with Nanometer-Scale Pores
ACS Sensors ( IF 8.2 ) Pub Date : 2018-01-30 00:00:00 , DOI: 10.1021/acssensors.7b00680
Haiyan Wang _{1,

2} , Jessica Ettedgui _{1,

3} , Jacob Forstater _{1,

3} , Joseph W. F. Robertson ₁ , Joseph E. Reiner ₄ , Huisheng Zhang ₂ , Siping Chen ₂ , John J. Kasianowicz _{1,

5}

Affiliation

Nanometer-scale pores have been developed for the detection, characterization, and quantification of a wide range of analytes (e.g., ions, polymers, proteins, anthrax toxins, neurotransmitters, and synthetic nanoparticles) and for DNA sequencing. We describe the key requirements that made this method possible and how the technique evolved. Finally, we show that, despite sound theoretical work, which advanced both the conceptual framework and quantitative capability of the method, there are still unresolved questions that need to be addressed to further improve the technique.

中文翻译：

用纳米级孔测定分子的物理性质

已开发出纳米级的孔，用于检测，表征和定量各种分析物（例如离子，聚合物，蛋白质，炭疽毒素，神经递质和合成纳米颗粒）并用于DNA测序。我们描述了使这种方法成为可能的关键要求以及该技术的发展方式。最后，我们表明，尽管进行了出色的理论工作，既提高了该方法的概念框架又提高了定量方法的能力，但仍需要解决一些尚未解决的问题，以进一步改进该技术。

更新日期：2018-01-30

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