当前位置: X-MOL 学术ACS Comb. Sci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Enediyne-Comprising Amino Aldehydes in the Passerini Reaction
ACS Combinatorial Science Pub Date : 2018-01-17 00:00:00 , DOI: 10.1021/acscombsci.7b00167
Mladena Glavaš 1 , Matija Gredičak 1 , Ivanka Jerić 1
Affiliation  

Multicomponent reactions represent a highly efficient approach to a broad spectrum of structurally diverse compounds starting from simple and affordable compounds. A focused library of tweezers-like compounds is prepared by employing the multicomponent Passerini reaction comprising enediyne-derived amino aldehydes. The reaction proceeds under mild conditions yielding Passerini products in good to excellent yields. Postcondensation modifications of Passerini products are demonstrated through a simple deprotection/coupling approach comprising amino functionality, furnishing enediyne cores with highly decorated arms.

中文翻译:

帕塞里尼反应中含烯二酮的氨基醛

多组分反应代表了一种高效的方法,从简单且价格合理的化合物开始,可用于处理多种结构多样的化合物。通过使用包含烯二炔衍生的氨基醛的多组分Passerini反应制备镊子状化合物的聚焦库。反应在温和的条件下进行,以良好的收率得到优质的Passerini产品。通过一种简单的脱保护/偶联方法(包括氨基官能团),为烯二炔核配备了高度修饰的臂,展示了Passerini产品的缩合后修饰。
更新日期:2018-01-17
down
wechat
bug