Untargeted Metabolomic Screen Reveals Changes in Human Plasma Metabolite Profiles Following Consumption of Fresh Broccoli Sprouts,Molecular Nutrition & Food Research

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Untargeted Metabolomic Screen Reveals Changes in Human Plasma Metabolite Profiles Following Consumption of Fresh Broccoli Sprouts
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2018-02-23 , DOI: 10.1002/mnfr.201700665
Lauren Housley _{1,

2} , Armando Alcazar Magana _{3,

4} , Anna Hsu ₁ , Laura M. Beaver ₁ , Carmen P. Wong ₁ , Jan F. Stevens _{3,

5} , Jaewoo Choi ₃ , Yuan Jiang ₆ , Deborah Bella ₁ , David E. Williams _{3,

7} , Claudia S. Maier ₄ , Jackilen Shannon ₈ , Roderick H. Dashwood ₉ , Emily Ho _{1,

3,

9,

10}

Affiliation

Several lines of evidence suggest that the consumption of cruciferous vegetables is beneficial to human health. Yet, underlying mechanisms and key molecular targets that are involved with achieving these benefits in humans are still not fully understood. To accelerate this research, we conduct a human study to identify potential molecular targets of crucifers for further study. This study aims to characterize plasma metabolite profiles in humans before and after consuming fresh broccoli sprouts (a rich dietary source of bioactive sulforaphane).

中文翻译：

未靶向的代谢组学筛选显示了新鲜西兰花芽苗食用后人体血浆代谢物谱的变化

有几条证据表明食用十字花科蔬菜有益于人体健康。然而，在人类中实现这些益处所涉及的潜在机制和关键分子靶点仍未被完全理解。为了加速这项研究，我们进行了一项人体研究，以鉴定十字花科植物的潜在分子靶标，以供进一步研究。这项研究旨在表征食用新鲜西兰花芽（富含生物活性萝卜硫素的丰富饮食来源）前后的人血浆代谢产物的特征。

更新日期：2018-02-23

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