Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy,Chemical Society Reviews

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Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2018-01-29 00:00:00 , DOI: 10.1039/c7cs00657h
Yong Hu _{1,

2,

3,

4,

5} , Serge Mignani _{6,

7,

8,

9,

10} , Jean-Pierre Majoral _{11,

12,

13} , Mingwu Shen _{1,

2,

3,

4,

5} , Xiangyang Shi _{1,

2,

3,

4,

5}

Affiliation

The aim of this original review is to highlight and analyze the most recent progress and challenges in the synthesis and surface modifications of superparamagnetic iron oxide (Fe₃O₄) nanoparticles (NPs) for multimodal imaging and therapy applications, which represent important fields in medicine in general and cancer in particular. Thus, the oncology domain is rapidly moving to a more personalized medicine including precision imaging and theranostic approaches. Novel biocompatible Fe₃O₄ nanoparticulate systems have been designed for enhanced and targeted cellular uptake by surface layer coating modifications, to have improved r₂ relaxivity for sensitive magnetic resonance (MR) imaging applications, to have the ability to be used for dual mode imaging, and to be used for imaging-guided cancer therapy. In this review, we analyzed in depth the new strategies for generating biocompatible multifunctional Fe₃O₄ nanoplatforms for both the diagnosis and therapy of cancer.

中文翻译：

基于氧化铁纳米粒子的肿瘤成像和治疗混合平台的构建

这篇原始评论的目的是突出和分析用于多峰成像和治疗应用的超顺磁性氧化铁（Fe ₃ O ₄）纳米颗粒（NPs）的合成和表面修饰的最新进展和挑战，这代表了医学领域的重要领域一般而言，尤其是癌症。因此，肿瘤学领域正在迅速转向更加个性化的药物，包括精确成像和治疗诊断方法。已设计出新颖的生物相容性Fe ₃ O ₄纳米颗粒系统，以通过表面涂层的修饰来增强和靶向细胞摄取，从而改善r _2。弛豫性用于敏感磁共振（MR）成像应用，具有用于双模成像和用于成像指导的癌症治疗的能力。在这篇综述中，我们深入分析了生成生物相容性多功能Fe ₃ O ₄纳米平台用于癌症诊断和治疗的新策略。

更新日期：2018-01-29

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