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Novel Modifications of Glycopeptide Antibiotics via Total Synthesis
ACS Medicinal Chemistry Letters ( IF 3.5 ) Pub Date : 2018-01-26 00:00:00 , DOI: 10.1021/acsmedchemlett.8b00029
David J. Newman 1
Affiliation  

Although vancomycin has been in clinical use since the late 1950s, resistance due to alteration in the target microbe’s peptidoglycan can vary significantly, reducing its activity. Total synthesis of derivatives has now led to a molecule with very significant activity against resistant strains.

中文翻译:

通过全合成对糖肽抗生素的新型修饰

尽管万古霉素自1950年代后期以来就已投入临床使用,但由于靶标微生物的肽聚糖发生变化而引起的耐药性可能会发生显着变化,从而降低其活性。衍生物的全合成现在已经导致了对抗性菌株具有非常显着活性的分子。
更新日期:2018-01-26
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