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The effect of vitamin C and iron on dopamine-mediated free radical generation: implications to Parkinson's disease†
Dalton Transactions ( IF 3.5 ) Pub Date : 2018-01-26 00:00:00 , DOI: 10.1039/c7dt04373b Yingying Sun 1, 2, 3, 4 , An Ninh Pham 1, 2, 3, 4 , T. David Waite 1, 2, 3, 4
Dalton Transactions ( IF 3.5 ) Pub Date : 2018-01-26 00:00:00 , DOI: 10.1039/c7dt04373b Yingying Sun 1, 2, 3, 4 , An Ninh Pham 1, 2, 3, 4 , T. David Waite 1, 2, 3, 4
Affiliation
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Parkinson's disease (PD) is the second most common neurodegenerative disorder in the world. The oxidative stress and DA derived quinones have been proposed to be closely related to the progression of PD. To examine the possibility of the application of ascorbate (Asc) as a therapeutic strategy in PD, the effect of Asc on the fate of iron both in the absence and presence of DA was investigated. The results of this study indicate that, in the absence of iron, the presence of high concentrations of Asc is of great benefit in view of the alleviation in oxidative stress and formation of DA derived quinones by quenching radicals, such as O2˙− and DA˙−. As a well-known reductant, the presence of high concentrations of Asc in iron enriched solution results in elevation in the concentration of active Fe(II), which poses a potential threat to health as a result of inefficient oxygenation. While a competition exists between Asc and DA, the higher affinity of DA towards iron coupled with the formation of the more stable FeIIIDA2 complex renders Asc unlikely to reduce the DA bound iron. The results of this study suggest that while the application of Asc alone may aggravate the progression of PD in view of the possible peroxidation of Asc bound Fe(II), a combination therapy of Asc and strong clinically used iron chelator would appear to be a promising direction for the treatment of PD as a result of the enhanced iron chelation and attenuation in oxidative stress and toxicity induced by DA derived quinones.
中文翻译：
维生素C和铁对多巴胺介导的自由基生成的影响：对帕金森氏病的影响†
帕金森氏病（PD）是世界上第二常见的神经退行性疾病。已经提出氧化应激和DA衍生的醌与PD的进展密切相关。为了检查将抗坏血酸（Asc）用作PD治疗策略的可能性，研究了在不存在和存在DA的情况下，Asc对铁命运的影响。这项研究的结果表明，在不存在铁的，高浓度的ASC的存在是有很大好处鉴于减轻的氧化应激和形成DA的淬火自由基衍生醌，如O 2 ˙ -和DA -。作为一种众所周知的还原剂，富铁溶液中高浓度的Asc的存在会导致活性Fe（II）浓度升高，这是由于氧合效率低而对健康造成的潜在威胁。虽然Asc和DA之间存在竞争，但DA对铁的亲和力更高，并且形成了更稳定的Fe III DA 2络合物，使得Asc不太可能还原与DA结合的铁。这项研究的结果表明，考虑到Asc结合的Fe（II）可能被过氧化，单独使用Asc可能会加重PD的进展。），由于增强的铁螯合作用以及DA衍生的醌引起的氧化应激和毒性的减弱，Asc和临床上广泛使用的铁螯合剂的联合治疗似乎是治疗PD的有希望的方向。
更新日期：2018-01-26
中文翻译：
维生素C和铁对多巴胺介导的自由基生成的影响：对帕金森氏病的影响†
帕金森氏病（PD）是世界上第二常见的神经退行性疾病。已经提出氧化应激和DA衍生的醌与PD的进展密切相关。为了检查将抗坏血酸（Asc）用作PD治疗策略的可能性，研究了在不存在和存在DA的情况下，Asc对铁命运的影响。这项研究的结果表明，在不存在铁的，高浓度的ASC的存在是有很大好处鉴于减轻的氧化应激和形成DA的淬火自由基衍生醌，如O 2 ˙ -和DA -。作为一种众所周知的还原剂，富铁溶液中高浓度的Asc的存在会导致活性Fe（II）浓度升高，这是由于氧合效率低而对健康造成的潜在威胁。虽然Asc和DA之间存在竞争，但DA对铁的亲和力更高，并且形成了更稳定的Fe III DA 2络合物，使得Asc不太可能还原与DA结合的铁。这项研究的结果表明，考虑到Asc结合的Fe（II）可能被过氧化，单独使用Asc可能会加重PD的进展。），由于增强的铁螯合作用以及DA衍生的醌引起的氧化应激和毒性的减弱，Asc和临床上广泛使用的铁螯合剂的联合治疗似乎是治疗PD的有希望的方向。
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