Designed transition metal catalysts for intracellular organic synthesis,Chemical Society Reviews

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Designed transition metal catalysts for intracellular organic synthesis
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2018-01-25 00:00:00 , DOI: 10.1039/c7cs00447h
Yugang Bai _{1,

2,

3,

4} , Junfeng Chen _{1,

2,

3,

4} , Steven C. Zimmerman _{1,

2,

3,

4}

Affiliation

The development of synthetic, metal-based catalysts to perform intracellular bioorthogonal reactions represents a relatively new and important area of research that combines transition metal catalysis and chemical biology. The ability to perform reactions in cellulo, especially those transformations without a natural counterpart, offers a versatile tool for medicinal chemists and chemical biologists. With proper modification of the metal catalysts, it is even possible to direct a reaction to certain intracellular sites. This review highlights advances in this new area, from early work on intracellular functional group conversions to recent advances in intracellular synthesis of drugs, including cytotoxic agents. Both the fundamental and applied aspects of this approach to intracellular synthesis are reviewed.

中文翻译：

设计用于细胞内有机合成的过渡金属催化剂

进行细胞内生物正交反应的合成金属基催化剂的开发是结合过渡金属催化和化学生物学研究的一个相对较新的重要领域。在纤维素中进行反应的能力，尤其是那些没有天然对应物的转化，为药物化学家和化学生物学家提供了一种多功能的工具。通过适当修饰金属催化剂，甚至可以将反应引导至某些细胞内位点。这篇综述重点介绍了这一新领域的进展，从细胞内官能团转化的早期工作到药物（包括细胞毒性剂）在细胞内合成方面的最新进展。审查了这种方法进行细胞内合成的基本方面和应用方面。

更新日期：2018-01-25

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