Synthesis ( IF 2.2 ) Pub Date : 2018-01-24 , DOI: 10.1055/s-0036-1591877 Sivaraman Balasubramaniam 1 , Ganapathy Sankaran 2 , Sneh Badle 1
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Dedicated to Professor Indrapal Singh Aidhen
Abstract
FTY720 {fingolimod hydrochloride, 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride}, a novel immunosuppressant, was discovered by chemical modification based on the structure activity relationships of ISP-I (myriocin), a metabolite of the fungus Isaria sinclairii. This short perspective provides insights to the various strategies available in the literature for the synthesis of FTY720 and its analogues.
1 Introduction
2 Classification of Immunosuppressive Drugs
3 The Rise of FTY720
4 Different Synthetic Strategies for FTY720
5 Analogues of FTY720
6 Binding Studies of FTY720
7 Mode of Action
8 Conclusion
FTY720 {fingolimod hydrochloride, 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride}, a novel immunosuppressant, was discovered by chemical modification based on the structure activity relationships of ISP-I (myriocin), a metabolite of the fungus Isaria sinclairii. This short perspective provides insights to the various strategies available in the literature for the synthesis of FTY720 and its analogues.
1 Introduction
2 Classification of Immunosuppressive Drugs
3 The Rise of FTY720
4 Different Synthetic Strategies for FTY720
5 Analogues of FTY720
6 Binding Studies of FTY720
7 Mode of Action
8 Conclusion
中文翻译：
免疫抑制剂FTY720的观点
献给Indrapal Singh Aidhen教授
抽象的
基于ISP-1的结构活性关系，通过化学修饰发现了一种新型的免疫抑制剂FTY720 {盐酸芬戈莫德，2-氨基-2- [2-（4-辛基苯基）乙基]丙烷-1,3-二醇盐} （myriocin），一种真菌Isaria sinclairii的代谢产物。这种简短的见解提供了对FTY720及其类似物合成文献中各种策略的见解。
1引言
2免疫抑制药的分类
3 FTY720的崛起
FTY720的4种不同合成策略
FTY720的5个类似产品
6 FTY720的结合研究
7行动方式
8结论
基于ISP-1的结构活性关系，通过化学修饰发现了一种新型的免疫抑制剂FTY720 {盐酸芬戈莫德，2-氨基-2- [2-（4-辛基苯基）乙基]丙烷-1,3-二醇盐} （myriocin），一种真菌Isaria sinclairii的代谢产物。这种简短的见解提供了对FTY720及其类似物合成文献中各种策略的见解。
1引言
2免疫抑制药的分类
3 FTY720的崛起
FTY720的4种不同合成策略
FTY720的5个类似产品
6 FTY720的结合研究
7行动方式
8结论
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