Tissue integrity is crucial for maintaining the homeostasis of living organisms. Abnormalities that affect sites of cell-cell contact can cause a variety of debilitating disorders. The desmosome is an essential cell-cell junctional protein complex in tissues that undergo stress, and it orchestrates intracellular signal transduction. Desmosome assembly and junctional integrity are required to maintain the overall homeostasis of a tissue, organ, and organism. This review discusses the desmosome and the human diseases associated with its disruption.

中文翻译：

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人类疾病中的桥粒

组织完整性对于维持活生物体的稳态至关重要。影响细胞与细胞接触部位的异常会导致各种使人衰弱的疾病。桥粒是承受压力的组织中必不可少的细胞-细胞连接蛋白复合物，它可以协调细胞内信号转导。为了维持组织，器官和生物体的整体稳态，需要进行桥粒组装和连接完整性。这篇综述讨论了桥粒和与其破坏有关的人类疾病。