Advances in Stimuli‐Responsive Polypeptide Nanogels,Small Methods

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Advances in Stimuli‐Responsive Polypeptide Nanogels
Small Methods ( IF 10.7 ) Pub Date : 2018-01-25 , DOI: 10.1002/smtd.201700307
Zhongyu Jiang ₁ , Jinjin Chen ₁ , Liguo Cui ₁ , Xiuli Zhuang ₁ , Jianxun Ding ₁ , Xuesi Chen ₁

Affiliation

Polymer nanogels, which are nanosized particles of hydrogels formed by physically or chemically crosslinking polymers, are one of the most promising nanoplatforms for use in biomedical applications, including drug delivery, gene therapy, and bioimaging. Polypeptide nanogels exhibit many advantages for applications in biomedical fields, including stable 3D structures, high drug‐loading efficiency, excellent biocompatibility, stimuli responsiveness, and so forth. More specifically, smart polypeptide nanogels undergo suitable transitions under endogenous (e.g., reduction, reactive oxygen species, pH, and enzymes) or exogenous stimuli (e.g., light, temperature, voltage, and magnetic fields) for on‐demand drug delivery. Here, a comprehensive introduction to the preparation and applications of diverse stimuli‐responsive polypeptide nanogels is given. Moreover, the opportunities and challenges of polypeptide nanogels for the development of biomedicine are briefly predicted.

中文翻译：

刺激反应性多肽纳米凝胶的研究进展

聚合物纳米凝胶是通过物理或化学交联聚合物形成的水凝胶的纳米级颗粒，是用于生物医学应用（包括药物递送，基因治疗和生物成像）的最有前途的纳米平台之一。多肽纳米凝胶在生物医学领域具有许多优势，包括稳定的3D结构，高载药效率，出色的生物相容性，刺激反应性等。更具体地说，智能多肽纳米凝胶在内源性（例如，还原性，活性氧，pH和酶）或外源性刺激（例如，光，温度，电压和磁场）下经历适当的转变，以按需递送药物。在此，对各种刺激响应性多肽纳米凝胶的制备和应用进行了全面介绍。

更新日期：2018-01-25

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