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Silver Nanoclusters Encapsulated into Metal–Organic Frameworks with Enhanced Fluorescence and Specific Ion Accumulation toward the Microdot Array-Based Fluorimetric Analysis of Copper in Blood
ACS Sensors ( IF 8.2 ) Pub Date : 2018-02-06 00:00:00 , DOI: 10.1021/acssensors.7b00874
Chuan Fan 1 , Xiaoxia Lv 1 , Fengjuan Liu 1 , Luping Feng 1 , Min Liu 1 , Yuanyuan Cai 1 , Huan Liu 1 , Jingyi Wang 1 , Yanli Yang 1 , Hua Wang 1
Affiliation  

Silver nanoclusters (AgNCs) were first coated with bovine serum albumin (BSA) and then encapsulated into porous metal–organic frameworks of ZIF-8 by the protein-mediated biomineralization process. Unexpectedly, the fluorescence intensities of the yielded [email protected] nanocomposites were discovered to be continuously enhanced during each of the BSA coating and ZIF-8 encapsulation steps. Compared to common AgNCs, greatly improved photostability and storage stability of AgNCs could also be expected. More importantly, having benefited from the ZIF-8 shells, the prepared nanocomposites could possess the specific accumulation and sensitive response to Cu2+ ions, resulting in the rational quenching of their fluorescence intensities. Moreover, [email protected] nanocomposites were coated onto the hydrophobic arraying slides toward a microdots array-based fluorimetric method for the fast and sensitive evaluation of Cu2+ ions. It was discovered that the developed fluorimetric strategy could ensure the high-throughput analysis of Cu2+ ions in wide pH range, and especially some harsh and high-salt media. It can allow for the detection of Cu2+ ions in blood with the concentrations ranging from 4.0 × 10–4 to 160 μM, thus serving as a new copper detection candidate to be widely applied in clinical test, food safety, and environmental monitoring fields.

中文翻译:

银纳米团簇被封装到具有增强的荧光性和特定离子积累的金属有机骨架中,从而对基于血液中铜的基于微点阵列的荧光分析进行了分析

首先用牛血清白蛋白(BSA)涂覆银纳米簇(AgNC),然后通过蛋白质介导的生物矿化过程将其包裹在ZIF-8的多孔金属有机框架中。出乎意料的是,发现在每个BSA涂层和ZIF-8封装步骤中,生成的[受电子邮件保护的]纳米复合材料的荧光强度都在不断提高。与普通的AgNC相比,也有望大大提高AgNC的光稳定性和存储稳定性。更重要的是,受益于ZIF-8壳,制备的纳米复合材料可以具有特定的积累和对Cu 2+的敏感响应。离子,导致其荧光强度的合理淬灭。此外,将[受电子邮件保护的]纳米复合材料涂在疏水性排列载玻片上,以基于微点阵列的荧光法进行,以便快速,灵敏地评估Cu 2+离子。已发现,开发的荧光分析策略可以确保在宽pH范围内,尤其是某些苛刻和高盐介质中对Cu 2+离子进行高通量分析。它可以检测血液中的Cu 2+离子,浓度范围为4.0×10 –4到160μM,从而成为一种广泛应用于临床测试,食品安全和环境监测领域的新型铜检测候选物。 。
更新日期:2018-02-06
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