Single Site Fluorination of the GM4 Ganglioside Epitope Upregulates Oligodendrocyte Differentiation,ACS Chemical Neuroscience

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Single Site Fluorination of the GM4 Ganglioside Epitope Upregulates Oligodendrocyte Differentiation
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-01-23 00:00:00 , DOI: 10.1021/acschemneuro.8b00002
Tobias J. Kieser _{1,

2} , Nico Santschi _{1,

2} , Luise Nowack ₃ , Gerald Kehr ₁ , Tanja Kuhlmann ₃ , Stefanie Albrecht ₃ , Ryan Gilmour _{1,

2}

Affiliation

Relapsing multiple sclerosis is synonymous with demyelination, and thus, suppressing and or reversing this process is of paramount clinical significance. While insulating myelin sheath has a large lipid composition (ca. 70–80%), it also has a characteristically large composition of the sialosylgalactosylceramide gangliosde GM₄ present. In this study, the effect of the carbohydrate epitope on oligodendrocyte differentiation is determined. While the native epitope had no impact on oligodendroglial cell viability, a single site OH → F substitution is the structural basis of a significant increase in ATP production that is optimal at 50 μg/mL. From a translational perspective, this subtle change increases the amount of MBP+ oligodendrocytes compared to the control studies and may open up novel therapeutic remyelination strategies.

中文翻译：

GM ₄神经节苷脂表位的单点氟化作用上调少突胶质细胞分化。

复发性多发性硬化症是脱髓鞘的代名词，因此，抑制和/或逆转该过程具有最重要的临床意义。绝缘的髓鞘护套具有较大的脂质成分（约占70–80％），而唾液酰半乳糖苷神经酰胺神经节苷脂GM _4的成分也很大展示。在这项研究中，确定了碳水化合物表位对少突胶质细胞分化的影响。尽管天然表位对少突胶质细胞的生存力没有影响，但是单点OH→F取代是ATP产量显着增加的结构基础，ATP产量显着增加，最佳浓度为50μg/ mL。从翻译的角度来看，与对照研究相比，这种细微的变化增加了MBP +少突胶质细胞的数量，并可能开辟了新颖的治疗性髓鞘再生策略。

更新日期：2018-01-23

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