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Labeling of Hyaluronic Acids with a Rhenium-tricarbonyl Tag and Percutaneous Penetration Studied by Multimodal Imaging
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2018-01-23 00:00:00 , DOI: 10.1021/acs.bioconjchem.7b00825 Lucas Henry 1 , Nicolas Delsuc 1 , Cécile Laugel 2 , François Lambert 1 , Christophe Sandt 3 , Sarah Hostachy 1 , Anne-Sophie Bernard 1 , Hélène C. Bertrand 1 , Laurence Grimaud 4 , Arlette Baillet-Guffroy 2 , Clotilde Policar 1
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2018-01-23 00:00:00 , DOI: 10.1021/acs.bioconjchem.7b00825 Lucas Henry 1 , Nicolas Delsuc 1 , Cécile Laugel 2 , François Lambert 1 , Christophe Sandt 3 , Sarah Hostachy 1 , Anne-Sophie Bernard 1 , Hélène C. Bertrand 1 , Laurence Grimaud 4 , Arlette Baillet-Guffroy 2 , Clotilde Policar 1
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Hyaluronic acids were labeled with a rhenium-tricarbonyl used as single core multimodal probe for imaging and their penetration into human skin biopsies was studied using IR microscopy and fluorescence imaging (labeled SCoMPI). The penetration was shown to be dependent on the molecular weight of the molecule and limited to the upper layer of the skin.
中文翻译：
带有三羰基Tag标签的透明质酸标记和经多模态成像研究的经皮穿透性
透明质酸用三羰基rh标记，用作单核多峰探针进行成像，并使用红外显微镜和荧光成像（标记为SCoMPI）研究了其在人皮肤活检组织中的渗透性。已表明渗透性取决于分子的分子量，并限于皮肤的上层。
更新日期：2018-01-23
中文翻译：
带有三羰基Tag标签的透明质酸标记和经多模态成像研究的经皮穿透性
透明质酸用三羰基rh标记，用作单核多峰探针进行成像，并使用红外显微镜和荧光成像（标记为SCoMPI）研究了其在人皮肤活检组织中的渗透性。已表明渗透性取决于分子的分子量，并限于皮肤的上层。
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