Concomitant ion effects on isotope ratio measurements with liquid sampling – atmospheric pressure glow discharge ion source Orbitrap mass spectrometry,Journal of Analytical Atomic Spectrometry

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Concomitant ion effects on isotope ratio measurements with liquid sampling – atmospheric pressure glow discharge ion source Orbitrap mass spectrometry
Journal of Analytical Atomic Spectrometry ( IF 3.1 ) Pub Date : 2018-01-23 00:00:00 , DOI: 10.1039/c7ja00308k
Edward D. Hoegg _{1,

2,

3,

4,

5} , R. Kenneth Marcus _{1,

2,

3,

4} , George J. Hager _{4,

5,

6,

7} , Garret L. Hart _{4,

5,

6,

7} , David W. Koppenaal _{4,

5,

6,

7}

Affiliation

In an effort to understand and improve the accuracy and precision of the liquid sampling-atmospheric pressure glow discharge (LS-APGD)/Orbitrap system, effects of concomitant ions on the acquired mass spectra are examined and presented. The LS-APGD/Orbitrap instrument system is capable of high quality isotope ratio measurements, which are of high analytical interest for nuclear non-proliferation detection applications. The presence of background and concomitant ions (water clusters, matrix, and other analytes) has presented limitations in earlier studies. In order to mitigate these effects, an alternative quadrupole-Orbitrap hybrid mass spectrometer was employed in this study. This instrument configuration has a quadrupole mass filter preceding the Orbitrap to filter-out undesired non-analyte ions. Results are presented for the analysis of U in the presence of Rb, Ag, Ba, and Pb as concomitants, each present at 0.5 μg mL⁻¹ concentration. Progressive filtering of each concomitant ion shows steadily improved U isotope ratio performance. Ultimately, a ²³⁵U/²³⁸U ratio of 0.007133, with a relative error of −2.1% and a relative standard deviation of 0.087% was achieved using this system, along with improved calibration linearity and lowered limits of detection. This performance is surprisingly good for an ion trap type mass spectrometry instrument.

中文翻译：

伴随液体采样的离子对同位素比测量的影响–大气压辉光放电离子源Orbitrap质谱

为了理解和提高液体采样-大气压辉光放电（LS-APGD）/ Orbitrap系统的准确性和精密度，研究并提出了伴随离子对所采集质谱的影响。LS-APGD / Orbitrap仪器系统能够进行高质量的同位素比测量，对于核不扩散检测应用具有很高的分析价值。背景离子和伴随离子（水簇，基质和其他分析物）的存在在早期研究中存在局限性。为了减轻这些影响，本研究中使用了另一种四极杆-Orbitrap混合质谱仪。该仪器配置在Orbitrap之前有一个四极质量过滤器，用于过滤掉不需要的非分析物离子。^-1浓度。每个伴随离子的逐步过滤显示出稳定提高的U同位素比性能。最终，使用该系统实现了²³⁵ U /²³⁸ U的比例为0.007133，相对误差为-2.1％，相对标准偏差为0.087％，同时还改善了校准线性和降低了检测限。对于离子阱型质谱仪，该性能出乎意料地好。

更新日期：2018-01-23

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