Release of small bioactive molecules from physical gels†,Chemical Society Reviews

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Release of small bioactive molecules from physical gels†
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2018-01-22 00:00:00 , DOI: 10.1039/c7cs00515f
Judith Mayr _{1,

2,

3,

4} , César Saldías _{5,

6,

7,

8,

9} , David Díaz Díaz _{1,

2,

3,

4,

10}

Affiliation

Pharmaceutical drugs with low water solubility have always received great attention within the scientific community. The reduced bioavailability and the need of frequent administrations have motivated the investigation of new drug delivery systems. Within this context, drug carriers that release their payload in a sustained way and hence reduce the administration rate are highly demanded. One interesting strategy to meet these requirements is the entrapment of the drugs into gels. So far, the most investigated materials for such drug-loaded gels are derived from polymers and based on covalent linkages. However, over the last decade the use of physical (or supramolecular) gels derived from low molecular weight compounds has experienced strong growth in this field, mainly due to important properties such as injectability, stimuli responsiveness and ease of synthesis. This review summarizes the use of supramolecular gels for the encapsulation and controlled release of small therapeutic molecules.

中文翻译：

从物理凝胶中释放出小的生物活性分子†

水溶性低的药物一直受到科学界的高度重视。生物利用度的降低和频繁给药的需求激发了对新药物递送系统的研究。在这种情况下，迫切需要能够持续释放其有效载荷并因此降低给药速率的药物载体。满足这些要求的一种有趣的策略是将药物截留在凝胶中。迄今为止，用于此类载药凝胶的研究最多的材料是衍生自聚合物并基于共价键。但是，在过去十年中，使用低分子量化合物衍生的物理（或超分子）凝胶在该领域经历了强劲的增长，这主要是由于重要的特性，例如可注射性，刺激反应性和易于合成。这篇综述总结了超分子凝胶在小治疗分子的包封和控制释放中的用途。

更新日期：2018-01-22

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