DNA Nanostructure‐Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides,Advanced Healthcare Materials

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DNA Nanostructure‐Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-01-22 , DOI: 10.1002/adhm.201701153
Qinqin Hu ₁ , Sheng Wang ₁ , Lihua Wang ₂ , Hongzhou Gu ₁ , Chunhai Fan ₂

Affiliation

In the beginning of the 21st century, therapeutic oligonucleotides have shown great potential for the treatment of many life‐threatening diseases. However, effective delivery of therapeutic oligonucleotides to the targeted location in vivo remains a major issue. As an emerging field, DNA nanotechnology is applied in many aspects including bioimaging, biosensing, and drug delivery. With sequence programming and optimization, a series of DNA nanostructures can be precisely engineered with defined size, shape, surface chemistry, and function. Simply with hybridization, therapeutic oligonucleotides including unmethylated cytosine–phosphate–guanine dinucleotide oligos, small interfering RNA (siRNA) or antisense RNA, single guide RNA of the regularly interspaced short palindromic repeat–Cas9 system, and aptamers, are successfully loaded on DNA nanostructures for delivery. In this progress report, the development history of DNA nanotechnology is first introduced, and then the mechanisms and means for cellular uptake of DNA nanostructures are discussed. Next, current approaches to deliver therapeutic oligonucleotides with DNA nanovehicles are summarized. In the end, the challenges and opportunities for DNA nanostructure‐based systems for the delivery of therapeutic oligonucleotides are discussed.

中文翻译：

基于DNA纳米结构的系统，可智能地提供治疗性寡核苷酸

在21世纪初，治疗性寡核苷酸在治疗许多威胁生命的疾病方面显示出巨大潜力。然而，将治疗性寡核苷酸有效递送至体内目标位置仍然是主要问题。作为一个新兴领域，DNA纳米技术已应用于许多领域，包括生物成像，生物传感和药物递送。通过序列编程和优化，可以精确地设计一系列具有定义的大小，形状，表面化学性质和功能的DNA纳米结构。通过杂交，治疗性寡核苷酸包括未甲基化的胞嘧啶-磷酸-鸟嘌呤二核苷酸寡核苷酸，小干扰RNA（siRNA）或反义RNA，规则间隔的短回文重复序列-Cas9系统的单个向导RNA和适体，已成功装载到DNA纳米结构上进行递送。在这份进展报告中，首先介绍了DNA纳米技术的发展历史，然后讨论了细胞吸收DNA纳米结构的机理和手段。接下来，总结了当前的利用DNA纳米载体递送治疗性寡核苷酸的方法。最后，讨论了基于DNA纳米结构的治疗性寡核苷酸递送系统所面临的挑战和机遇。

更新日期：2018-01-22

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