Pd‐Catalyzed One‐Pot Dehydroxylative Coupling of Phenols and Amines under a Carbon Monoxide Atmosphere: A Chemical‐Specific Discrimination for Arylcarboxylic Amide Synthesis,Asian Journal of Organic Chemistry

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Pd‐Catalyzed One‐Pot Dehydroxylative Coupling of Phenols and Amines under a Carbon Monoxide Atmosphere: A Chemical‐Specific Discrimination for Arylcarboxylic Amide Synthesis
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2018-02-09 , DOI: 10.1002/ajoc.201800037
Wan-Yin Fang ₁ , Yu-Mei Huang ₁ , Jing Leng ₁ , Hua-Li Qin ₁

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A simple one‐pot process for the synthesis of amides through Pd‐catalyzed dehydroxylative coupling of phenols and amines with the insertion of carbon monoxide was developed. This protocol afforded exclusive chemical selectivity for accessing arylcarboxylic amides from phenols by using acyclic amines. The same reaction provided sulfonamides if cyclic amines were used. The reaction proceeds smoothly under mild conditions and tolerates a variety of functional groups. The versatility of this method represents an alternative to the known processes for the preparation of amides.

中文翻译：

一氧化碳气氛下Pd催化的苯酚和胺的一锅脱羟基偶联：芳基酰胺的化学特定区分

开发了一种简单的单锅合成方法，该方法通过Pd催化的苯酚和胺的脱羟基偶联以及一氧化碳的插入来合成酰胺。该方案为使用无环胺从酚类中获得芳基羧酸酰胺提供了唯一的化学选择性。如果使用环胺，则相同的反应提供了磺酰胺。该反应在温和条件下平稳进行，并能耐受各种官能团。该方法的多功能性代表了制备酰胺的已知方法的替代方法。

更新日期：2018-02-09

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