当前位置: X-MOL 学术J. Food Sci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The Hepatoprotective Effect of Selenium-Enriched Yeast and Gum Arabic Combination on Carbon Tetrachloride-Induced Chronic Liver Injury in Rats
Journal of Food Science ( IF 3.2 ) Pub Date : 2018-01-19 , DOI: 10.1111/1750-3841.14030
Mohammed Hamid 1, 2, 3 , Yassin Abdulrahim 1, 2, 3 , Dandan Liu 1, 2 , Gang Qian 1, 2 , Alamzeb Khan 1, 2 , Kehe Huang 1, 2
Affiliation  

The antioxidant and anti-inflammatory effects of selenium-enriched yeast (SY) and Gum Arabic (GA) have been reported. This study aimed to determine the hepatoprotective effect of SY and GA combination on carbon tetrachloride (CCl4 )-induced chronic liver injury in rats and to explore their synergistic mechanisms of action. Forty adult male Wistar rats randomly allotted to 5 groups: (A) worked as control, (B) was administered CCl4 , (C-E) were fed daily by GA, SY, and GA+SY respectively after mixing with basal diet, following CCl4 -intoxication. GA and SY combination significantly ameliorated CCl4 -induced reduction in serum total protein with elevation in aspartate transaminase (AST) and alanine transaminase (ALT) in addition to restoring the histopathological changes and hepatic content of hydroxyproline. GA and SY combination was also effective in reducing lipid peroxidation (MDA), consistent with an increase in total antioxidant capacity (T-AOC), glutathione (GSH), superoxide dismutase (SOD) activities, indicating the suppression of liver oxidative stress. Furthermore, liver inflammation was ameliorated by GA and SY combination through inhibition of nuclear factor-kappa (NF-κB), tumor necrosis factor-alpha (TNF-α), cyclooxygenase-2(COX-2), monocyte chemotactic protein-1 (MCP-1), and toll-like receptor 4(TLR-4) over expression in the liver. Moreover, the up-regulation of proliferating cell nuclear antigen (PCNA) expression by GA and SY combination enhanced the regeneration of liver tissue after CCl4 -administration. The expression of Collagen1, alpha-smooth muscle actin (α-SMA), and transforming growth factor-beta1 (TGFβ1), was obviously ameliorated by GA and SY combination, suggesting the amelioration of profibrotic response of the liver. Taken together, our current study suggests that GA and SY combination exhibit a significant hepatoprotective activity, which more efficient than GA or SY alone. PRACTICAL APPLICATION Chronic liver diseases are the serious health problems, which increase the morbidity and mortality in the world today. Selenium-enriched yeast (SY) and Gum Arabic (GA) combination might be potential dietary agents could obviously ameliorate chronic liver damage, higher than GA and SY alone. They act to suppress the inflammation and inhibit the profibrotic response as well as support the liver regeneration.

中文翻译:

富硒酵母与阿拉伯树胶联合对四氯化碳致大鼠慢性肝损伤的保肝作用

富硒酵母 (SY) 和阿拉伯胶 (GA) 的抗氧化和抗炎作用已有报道。本研究旨在确定SY和GA组合对四氯化碳(CCl4)致大鼠慢性肝损伤的保肝作用,并探讨它们的协同作用机制。将 40 只成年雄性 Wistar 大鼠随机分为 5 组:(A) 作为对照,(B) 给予 CCl4,(CE) 与基础日粮混合后分别每天喂食 GA、SY 和 GA+SY,继 CCl4 -陶醉。除了恢复组织病理学变化和羟脯氨酸的肝含量外,GA 和 SY 组合显着改善了 CCl4 诱导的血清总蛋白降低,同时天冬氨酸转氨酶 (AST) 和丙氨酸转氨酶 (ALT) 升高。GA 和 SY 组合在降低脂质过氧化 (MDA) 方面也有效,这与总抗氧化能力 (T-AOC)、谷胱甘肽 (GSH)、超氧化物歧化酶 (SOD) 活性的增加一致,表明抑制了肝脏氧化应激。此外,GA和SY组合通过抑制核因子-κ(NF-κB)、肿瘤坏死因子-α(TNF-α)、环氧合酶-2(COX-2)、单核细胞趋化蛋白-1来改善肝脏炎症。 MCP-1) 和 toll 样受体 4 (TLR-4) 在肝脏中过度表达。此外,GA 和 SY 组合上调增殖细胞核抗原 (PCNA) 表达促进了 CCl4 给药后肝组织的再生。Collagen1、α-平滑肌肌动蛋白 (α-SMA) 和转化生长因子-β1 (TGFβ1) 的表达,GA和SY组合明显改善了肝脏的促纤维化反应。总之,我们目前的研究表明,GA 和 SY 组合表现出显着的保肝活性,比单独使用 GA 或 SY 更有效。实际应用 慢性肝病是严重的健康问题,它增加了当今世界的发病率和死亡率。富硒酵母 (SY) 和阿拉伯树胶 (GA) 组合可能是潜在的膳食剂,可以明显改善慢性肝损伤,高于单独使用 GA 和 SY。它们起到抑制炎症和抑制促纤维化反应以及支持肝脏再生的作用。我们目前的研究表明,GA 和 SY 组合表现出显着的保肝活性,比单独使用 GA 或 SY 更有效。实际应用 慢性肝病是严重的健康问题,它增加了当今世界的发病率和死亡率。富硒酵母 (SY) 和阿拉伯树胶 (GA) 组合可能是潜在的膳食剂,可以明显改善慢性肝损伤,高于单独使用 GA 和 SY。它们起到抑制炎症和抑制促纤维化反应以及支持肝脏再生的作用。我们目前的研究表明,GA 和 SY 组合表现出显着的保肝活性,比单独使用 GA 或 SY 更有效。实际应用 慢性肝病是严重的健康问题,它增加了当今世界的发病率和死亡率。富硒酵母 (SY) 和阿拉伯树胶 (GA) 组合可能是潜在的膳食剂,可以明显改善慢性肝损伤,高于单独使用 GA 和 SY。它们起到抑制炎症和抑制促纤维化反应以及支持肝脏再生的作用。富硒酵母 (SY) 和阿拉伯树胶 (GA) 组合可能是潜在的膳食剂,可以明显改善慢性肝损伤,高于单独使用 GA 和 SY。它们起到抑制炎症和抑制促纤维化反应以及支持肝脏再生的作用。富硒酵母 (SY) 和阿拉伯树胶 (GA) 组合可能是潜在的膳食剂,可以明显改善慢性肝损伤,高于单独使用 GA 和 SY。它们起到抑制炎症和抑制促纤维化反应以及支持肝脏再生的作用。
更新日期:2018-01-19
down
wechat
bug