Alzheimer's disease (AD) is a common neurodegenerative disorder, and oxidative stress plays a vital role in its progression. Antarctic krill oil (AKO) is rich in polyunsaturated fatty acids, which has various biological activities, such as improving insulin sensitivity, alleviating inflammation and ameliorating oxidative stress. In this study, the protective effect of AKO against AD were investigated in senescence-accelerated prone mouse strain 8 (SAMP8) mice. Results showed that treatment with AKO could effectively ameliorate learning and memory deficits and ease the anxiety in SAMP8 mice by Morris water maze, Barnes maze test and open-field test. Further analysis indicated that AKO might reduce β-amyloid (Aβ) accumulation in hippocampus through decreasing the contents of malondialdehyde (MDA) and 7,8-dihydro-8-oxoguanine (8-oxo-G), increasing the superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in the brain of SAMP8 mice. PRACTICAL APPLICATION The results of Morris water maze, Barnes maze test and open-field test indicated that Antarctic krill oil (AKO) improved the cognitive function and anxiety of SAMP8 mice. AKO reduced the Aβ42 level in hippocampus of SAMP8 mice. AKO ameliorated oxidative stress in brain rather than in serum and liver of SAMP8 mice.

中文翻译：

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南极磷虾油通过抑制衰老加速易发小鼠品系 8 (SAMP8) 小鼠大脑中的氧化应激对认知功能的保护作用

阿尔茨海默病（AD）是一种常见的神经退行性疾病，氧化应激在其进展中起着至关重要的作用。南极磷虾油（AKO）富含多不饱和脂肪酸，具有提高胰岛素敏感性、减轻炎症和改善氧化应激等多种生物活性。在这项研究中，AKO 对 AD 的保护作用在衰老加速易感小鼠品系 8 (SAMP8) 小鼠中进行了研究。结果表明，通过Morris水迷宫、Barnes迷宫试验和旷场试验，AKO治疗可有效改善SAMP8小鼠的学习和记忆缺陷，缓解焦虑。进一步分析表明，AKO 可能通过降低丙二醛 (MDA) 和 7,8-dihydro-8-oxoguanine (8-oxo-G) 的含量来减少海马中 β-淀粉样蛋白 (Aβ) 的积累，增加 SAMP8 小鼠大脑中的超氧化物歧化酶 (SOD) 和谷胱甘肽过氧化物酶 (GSH-Px) 活性。实际应用 Morris水迷宫、Barnes迷宫试验和旷场试验结果表明，南极磷虾油（AKO）改善了SAMP8小鼠的认知功能和焦虑。AKO 降低了 SAMP8 小鼠海马中的 Aβ42 水平。AKO 改善了大脑中的氧化应激，而不是 SAMP8 小鼠的血清和肝脏中的氧化应激。