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Rhodium(III)-Catalyzed Directed C–H Coupling with Methyl Trifluoroacrylate: Diverse Synthesis of Fluoroalkenes and Heterocycles
Organic Letters ( IF 4.9 ) Pub Date : 2018-01-19 00:00:00 , DOI: 10.1021/acs.orglett.7b03677
Tian-Jun Gong 1 , Meng-Yu Xu 1 , Shang-Hai Yu 1 , Chu-Guo Yu 1 , Wei Su 1 , Xi Lu 1 , Bin Xiao 1 , Yao Fu 1
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An example of Rh-catalyzed C–H activation with methyl trifluoroacrylate for the synthesis of fluoroolefins and heterocycles (benzoindolizines) is reported. The types of products were determined by the directing group. The benzoindolizines and fluoroolefins were obtained by using pyridine and pyrazole as the directing group, correspondingly. These transformations present a number of advantages, such as oxidant-free reaction conditions and broad functional group tolerance. Moreover, this reaction greatly extends the application of fluoroolefins.

中文翻译:

铑(III)催化的直接CH偶联三氟丙烯酸甲酯:氟代烯烃和杂环的多元合成

报道了用三氟丙烯酸甲酯进行Rh催化的C–H活化以合成氟烯烃和杂环(苯并吲哚并二氮杂苯)的例子。产品类型由指导小组决定。相应地,通过使用吡啶和吡唑作为指导基团获得苯并吲哚并二酮和氟代烯烃。这些转化具有许多优点,例如无氧化剂的反应条件和宽泛的官能团耐受性。而且,该反应极大地扩展了氟代烯烃的应用。
更新日期:2018-01-19
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