Abstract Halloysite-cyclodextrin hybrid was employed as carrier for sustained release of clotrimazole for vaginal or buccal treatment of Candidiasis. The nanocarrier was obtained by functionalization of halloysite surface with cyclodextrin moieties by means of microwave irradiation, with the final goal to obtain a scaffold for the covalent linkage of cysteamine hydrochloride. The interaction between clotrimazole and the pristine components, namely cyclodextrin and halloysite, was thoroughly investigated by several techniques such as DSC, TGA, UV–vis spectroscopy and some adsorption studies were, also, carried out. The release of the antifungine molecule was finally investigated in a medium that imitates the physiological conditions.

中文翻译：

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功能化埃洛石纳米管：抗真菌药物的高效载体系统

摘要 埃洛石-环糊精杂化物作为克霉唑缓释载体用于阴道或口腔念珠菌病的治疗。纳米载体是通过微波辐射用环糊精部分对埃洛石表面进行功能化获得的，最终目标是获得半胱胺盐酸盐共价连接的支架。克霉唑与原始组分（即环糊精和埃洛石）之间的相互作用通过 DSC、TGA、UV-vis 光谱等多种技术进行了彻底研究，并且还进行了一些吸附研究。最终在模拟生理条件的介质中研究了抗真菌分子的释放。