Bar adsorptive microextraction (BAμE) with a polymeric sorbent for the determination of emerging contaminants in water samples by ultra-high performance liquid chromatography with tandem mass spectrometry,Analytical Methods

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Bar adsorptive microextraction (BAμE) with a polymeric sorbent for the determination of emerging contaminants in water samples by ultra-high performance liquid chromatography with tandem mass spectrometry
Analytical Methods ( IF 2.7 ) Pub Date : 2018-01-19 00:00:00 , DOI: 10.1039/c7ay02792c
M. P. de Souza _{1,

2,

3,

4,

5} , T. M. Rizzetti _{1,

2,

3,

4,

5} , J. Z. Francesquett _{1,

2,

3,

4,

5} , O. D. Prestes _{1,

2,

3,

4,

5} , R. Zanella _{1,

2,

3,

4,

5}

Affiliation

In this study, a simple and sensitive method was established and validated for the determination of 13 emerging contaminants, representative of pharmaceuticals, hormones, plasticizers and flame retardants, in water using bar adsorptive microextraction (BAμE) followed by ultra-high performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS). Different coating phases (Oasis® HLB, C18 and GCB) were evaluated and the preparation, stability tests and development of the BAμE device are discussed. In order to select the best combination of experimental conditions for extraction and back extraction, a central composite design was applied. The polymeric sorbent Oasis® HLB presented the best performance. Validation results were satisfactory, since the method presented recoveries between 74 and 118% with relative standard deviations (RSDs) < 19%. In terms of analytical performance, method detection limits from 0.012 to 0.6 μg L⁻¹ were obtained. The proposed method combines a simple and effective multiple sample preparation step for the determination of emerging contaminants of different classes in water using BAμE followed by UHPLC-MS/MS analysis. The method applicability was evaluated using surface and drinking water and 6 positive samples were found indicating the presence of bisphenol A (0.08 to 0.665 μg L⁻¹) and paracetamol (0.104 to 4.2 μg L⁻¹).

中文翻译：

棒吸附微萃取（BAμE）和聚合物吸附剂通过串联质谱超高效液相色谱法测定水样品中的新兴污染物

在这项研究中，建立了一种简单而灵敏的方法，并通过棒吸附微萃取（BAμE）然后超高效液相色谱与质谱法测定水中的13种新兴污染物（代表药物，激素，增塑剂和阻燃剂）的含量得到了验证。串联质谱（UHPLC-MS / MS）。评估了不同的涂层阶段（Oasis®HLB，C18和GCB），并讨论了BAμE装置的制备，稳定性测试和开发。为了选择提取和反提取的实验条件的最佳组合，应用了中央复合设计。聚合物吸附剂Oasis®HLB表现出最佳性能。验证结果令人满意，因为该方法的回收率在74％至118％之间，相对标准偏差（RSD）<19％。就分析性能而言，方法检测限为0.012至0.6μgL获得^-1。所提出的方法结合了简单有效的多样品制备步骤，使用BAμE进行UHPLC-MS / MS分析，从而确定水中不同类别的新兴污染物。使用地表水和饮用水评估了该方法的适用性，发现6个阳性样品表明存在双酚A（0.08至0.665μgL^-1）和对乙酰氨基酚（0.104至4.2μgL^-1）。

更新日期：2018-01-19

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