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Lysine-derived, pH-sensitive and biodegradable poly(beta-aminoester urethane) networks and their local drug delivery behaviour†
Soft Matter ( IF 2.9 ) Pub Date : 2018-01-19 00:00:00 , DOI: 10.1039/c7sm01886j Yasemin Tamer 1, 2, 3, 4 , Biqiong Chen 5, 6, 7, 8
Soft Matter ( IF 2.9 ) Pub Date : 2018-01-19 00:00:00 , DOI: 10.1039/c7sm01886j Yasemin Tamer 1, 2, 3, 4 , Biqiong Chen 5, 6, 7, 8
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In this study, a series of covalently crosslinked, L-lysine based poly(beta-aminoester urethane) (LPBAEU) networks with good biodegradability and pH sensitivity was reported. The effect of hydrophilic/hydrophobic characteristics and diacrylate/amine molar ratio on the structure, swelling and degradation behaviour of the networks was investigated. The water transport mechanism and dynamic swelling behavior of the LPBAEU networks were strongly affected by medium pH, and swelling amounts up to 252.2% and 148.7% were observed at pH 5.6 and pH 7.4, respectively. It was found that water diffusion within the networks followed a non-Fickian mechanism. The LPBAEU network with the highest diacrylate/amine molar ratio exhibited the highest tensile strength and Young's modulus. In vitro mass losses of networks showed that the degradation rate of LPBAEU networks can be adjusted from 4 to 14 days. LPBAEU networks also supported loading of doxycycline hyclate (DH) and in vitro release studies demonstrated that release of DH from the networks was substantially hindered in the neutral pH environment, with 20.9–56.2% DH release, whereas DH release was accelerated under mild acidic conditions, with a release percentage of 36.6–99.6%. The release data were fitted to different mathematical models and the obtained results confirmed that these networks released DH in a non-Fickian mechanism. The results of this research support the idea that pH-responsive LPBAEU networks may find potential applications in local drug delivery.
中文翻译：
赖氨酸衍生，对pH敏感且可生物降解的聚（β-氨基酯氨基甲酸酯）网络及其局部药物递送行为†
在这项研究中，报告了一系列具有良好生物降解性和pH敏感性的基于L赖氨酸的共价交联聚（β-氨基酯氨基甲酸酯）（LPBAEU）网络。研究了亲水/疏水特性和二丙烯酸酯/胺的摩尔比对网络结构，溶胀和降解行为的影响。LPBAEU网络的水传输机制和动态溶胀行为受中等pH值的强烈影响，在pH 5.6和pH 7.4时，溶胀量分别达到252.2％和148.7％。发现网络中的水扩散遵循非菲克机制。具有最高的二丙烯酸酯/胺摩尔比的LPBAEU网络表现出最高的拉伸强度和杨氏模量。体外网络的质量损失表明，LPBAEU网络的退化率可以在4到14天之间进行调整。LPBAEU网络还支持盐酸多西环素（DH）的加载，并且体外释放研究表明，在中性pH环境中，DH从网络中的释放受到显着阻碍，DH释放为20.9-56.2％，而在温和的酸性条件下，DH的释放会加速，释放百分比为36.6–99.6％。释放数据适合于不同的数学模型，并且获得的结果证实了这些网络以非菲克机制释放了DH。这项研究的结果支持以下观点：pH响应型LPBAEU网络可能会在局部药物输送中找到潜在的应用。
更新日期：2018-01-19
中文翻译：
赖氨酸衍生，对pH敏感且可生物降解的聚（β-氨基酯氨基甲酸酯）网络及其局部药物递送行为†
在这项研究中，报告了一系列具有良好生物降解性和pH敏感性的基于L赖氨酸的共价交联聚（β-氨基酯氨基甲酸酯）（LPBAEU）网络。研究了亲水/疏水特性和二丙烯酸酯/胺的摩尔比对网络结构，溶胀和降解行为的影响。LPBAEU网络的水传输机制和动态溶胀行为受中等pH值的强烈影响，在pH 5.6和pH 7.4时，溶胀量分别达到252.2％和148.7％。发现网络中的水扩散遵循非菲克机制。具有最高的二丙烯酸酯/胺摩尔比的LPBAEU网络表现出最高的拉伸强度和杨氏模量。体外网络的质量损失表明，LPBAEU网络的退化率可以在4到14天之间进行调整。LPBAEU网络还支持盐酸多西环素（DH）的加载，并且体外释放研究表明，在中性pH环境中，DH从网络中的释放受到显着阻碍，DH释放为20.9-56.2％，而在温和的酸性条件下，DH的释放会加速，释放百分比为36.6–99.6％。释放数据适合于不同的数学模型，并且获得的结果证实了这些网络以非菲克机制释放了DH。这项研究的结果支持以下观点：pH响应型LPBAEU网络可能会在局部药物输送中找到潜在的应用。
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