Selectfluor-mediated regioselective nucleophilic functionalization of N-heterocycles under metal- and base-free conditions,Green Chemistry

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Selectfluor-mediated regioselective nucleophilic functionalization of N-heterocycles under metal- and base-free conditions
Green Chemistry ( IF 9.3 ) Pub Date : 2018-01-19 00:00:00 , DOI: 10.1039/c7gc03106h
Long-Yong Xie _{1,

2,

3,

4} , Jie Qu _{1,

2,

3,

4} , Sha Peng _{1,

2,

3,

4} , Kai-Jian Liu _{1,

2,

3,

4} , Zheng Wang _{1,

2,

3,

4} , Man-Hua Ding _{1,

2,

3,

4} , Yi Wang _{1,

2,

3,

4} , Zhong Cao _{4,

5,

6,

7} , Wei-Min He _{1,

2,

3,

4,

5}

Affiliation

A practical and environmentally attractive methodology for the direct diversification of N-heterocycles at ambient temperature under open-air conditions was developed. The obvious advantage of the process is that no toxic reagent, transition metal, base or other additive is employed, thus greatly reducing costs, facilitating post-reaction neutralization and purification and minimizing the environmental impact.

中文翻译：

在无金属和无碱条件下Selectfluor介导的N-杂环的区域选择性亲核功能化

开发了一种实用且对环境有吸引力的方法，用于在露天条件下在环境温度下使N杂环直接多样化。该方法的明显优点是不使用有毒试剂，过渡金属，碱或其他添加剂，从而大大降低了成本，促进了反应后中和和纯化，并将对环境的影响降至最低。

更新日期：2018-02-06

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